التفاصيل البيبلوغرافية
| العنوان: |
Simultaneous determination of 16 preservatives, sunscreens and anti-dandruffs in cosmetics by HPLC. (English) |
| المؤلفون: |
Yan Chen, Xijun Bao, Xiufang Yan, Jianning Liu, Fang Guo, Wenxia Niu |
| المصدر: |
China Surfactant Detergent & Cosmetics; Mar2022, Vol. 52 Issue 3, p337-344, 8p |
| مصطلحات موضوعية: |
SUNSCREENS (Cosmetics), HIGH performance liquid chromatography, GRADIENT elution (Chromatography), SOLVENT extraction, AQUEOUS solutions, BENZOIC acid |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
A method based on HPLC was established for the determination of 16 components in cosmetics including 10 types of preservatives, 4 types of sunscreens and 2 types of anti-dandruffs. The amount of 0.5 g of the cosmetic product was dissolved in methanol in a 10 mL volumetric flask and was ultrasonically extracted for 30 min. The extract was filtered through a 0.22 μm membrane, and then 10 μL solution was introduced onto an Eclipse Plus C18 column (250 mmx0.46 mmx5 μm) with methanol-0.5 mmol/L EDTA-2Na aqueous solution (pH=3.06) as mobile phase by gradient elution. The 16 components were separated at multiple wavelengths of the DAD detector. These preservatives, sunscreen agents and anti-dandruffs could be analyzed within 50 min simultaneously. The external standard method was employed for quantitative determination. The relative standard deviation of the method is 2.2%- 6.5%, and the recovery is 90.9%-109.7%. The limits of detection (LODs, S/N=3) and limits of quantification (LOQs, S/N=10) of 16 components were determined. By this method, different extraction solvent, extraction time and mobile phase were compared. Among these, methanol is used as extraction solvent for 30 minutes and methanol-0.5 mmol/L EDTA-2Na aqueous solution (pH=3.06) as mobile phase shows good linear relationship in their respective mass concentration range, with the correlation coefficients higher than 0.999 0. This method has high accuracy and precision. 30 products in the market were analyzed, and the results show that phenoxyethanol, benzoic acid, and methyl 4-hydroxybenzoate are the most commonly added preservatives in cosmetics. For the four sunscreens, octyl 4-methoxycinnamate is the most frequently added. Ketoconazole is not detected in these products. In these products, all of the 16 components are lower than the relevant limits in China. This method provides technical support for market supervision and laboratory testing, which also can meet their practical testing requirements. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
