التفاصيل البيبلوغرافية
| العنوان: |
Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer. |
| المؤلفون: |
Calabrese, Fiorella, Pezzuto, Federica, Lunardi, Francesca, Fortarezza, Francesco, Tzorakoleftheraki, Sofia-Eleni, Resi, Maria Vittoria, Tiné, Mariaenrica, Pasello, Giulia, Hofman, Paul |
| المصدر: |
International Journal of Molecular Sciences; Apr2022, Vol. 23 Issue 8, p4164-4164, 28p |
| مصطلحات موضوعية: |
NON-small-cell lung carcinoma, NEUROENDOCRINE cells, EPIDERMAL growth factor receptors, SMALL cell carcinoma, SQUAMOUS cell carcinoma, NEUROENDOCRINE tumors, ONCOGENES |
| مستخلص: |
Patients with non-small cell lung cancer, especially adenocarcinomas, harbour at least one oncogenic driver mutation that can potentially be a target for therapy. Treatments of these oncogene-addicted tumours, such as the use of tyrosine kinase inhibitors (TKIs) of mutated epidermal growth factor receptor, have dramatically improved the outcome of patients. However, some patients may acquire resistance to treatment early on after starting a targeted therapy. Transformations to other histotypes—small cell lung carcinoma, large cell neuroendocrine carcinoma, squamous cell carcinoma, and sarcomatoid carcinoma—have been increasingly recognised as important mechanisms of resistance and are increasingly becoming a topic of interest for all specialists involved in the diagnosis, management, and care of these patients. This article, after examining the most used TKI agents and their main biological activities, discusses histological and molecular transformations with an up-to-date review of all previous cases published in the field. Liquid biopsy and future research directions are also briefly discussed to offer the reader a complete and up-to-date overview of the topic. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder