التفاصيل البيبلوغرافية
| العنوان: |
Possible pathogenetic role of new cytokines in postmenopausal osteoporosis and changes during calcitonin plus calcium therapy. |
| المؤلفون: |
G&ür, Ali, Denli, Aziz, Nas, Kemal, Cevik, Remzi, Karakoc, Mehmet, Sarac, Aysegul Jale, Erdogan, Ferda |
| المصدر: |
Rheumatology International; Sep2002, Vol. 22 Issue 5, p194-198, 5p |
| مصطلحات موضوعية: |
SERUM, CYTOKINES, CALCITONIN, BONE diseases, WOMEN, THERAPEUTICS |
| مستخلص: |
The present study was designed to test if the serum cytokines (interleukin, or IL-1β, -2, -2r, -6, -6r, -8, and -10, and tumor necrosis factor α, or TNF-α) and osteocalcin levels were different between 50 osteoporotic and 30 postmenopausal nonosteoporotic women and to evaluate the efficacy of calcitonin therapy during 6 months on serum cytokines and osteocalcin levels in postmenopausal osteoporotic women. In our study, serum levels of osteocalcin, TNF-α, IL-2, and IL-8 were significantly higher in the patient group (P<0.05), whereas serum levels of IL-10 and IL-6r were significantly lower in the patient group (P<0.05). When analysed separately according to bone turnover, serum levels of IL-10 and IL-6r were significantly lower in the normal-turnover group (P<0.05), and IL-2, IL-8, and TNF-α were significantly higher in the high-turnover group than in the control group (P<0.05). Statistically significant improvement seemed to happen in the patients receiving calcitonin plus calcium therapy (P<0.05) concerning levels of serum IL-6r at the 1st month (P<0.05), IL-10, IL-2r, IL-6r, and osteocalcin at the 3rd month, and IL-6r and osteocalcin at the end of the 6th month. Our findings demonstrate that calcitonin plus calcium therapy appears to be particularly more effective for patients with high turnover. In addition, our study suggests that IL-10 and IL-6r may have an important role in normal-turnover osteoporosis, while IL-2, IL-8, and TNF-α may play an important role in high-turnover postmenopausal osteoporosis. [ABSTRACT FROM AUTHOR] |
|
Copyright of Rheumatology International is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder