التفاصيل البيبلوغرافية
| العنوان: |
The Immediate Effects of a Combined Mass Drug Administration and Indoor Residual Spraying Campaign to Accelerate Progress Toward Malaria Elimination in Grande-Anse, Haiti. |
| المؤلفون: |
Druetz, Thomas, Stresman, Gillian, Ashton, Ruth A, Joseph, Vena, van den Hoogen, Lotus, Worges, Matt, Hamre, Karen E S, Fayette, Carl, Monestime, Frank, Impoinvil, Daniel, Rogier, Eric, Chang, Michelle A, Lemoine, Jean Frantz, Drakeley, Chris, Eisele, Thomas P |
| المصدر: |
Journal of Infectious Diseases; May2022, Vol. 225 Issue 9, p1611-1620, 10p |
| مصطلحات موضوعية: |
DRUG administration, MALARIA, PLASMODIUM falciparum, CONFIDENCE intervals, INSECTICIDES, MALARIA prevention, DRUG therapy for malaria, PEST control, RESEARCH funding |
| مصطلحات جغرافية: |
HAITI |
| مستخلص: |
Background: Haiti is planning targeted interventions to accelerate progress toward malaria elimination. In the most affected department (Grande-Anse), a combined mass drug administration (MDA) and indoor residual spraying (IRS) campaign was launched in October 2018. This study assessed the intervention's effectiveness in reducing Plasmodium falciparum prevalence.Methods: An ecological quasi-experimental study was designed, using a pretest and posttest with a nonrandomized control group. Surveys were conducted in November 2017 in a panel of easy access groups (25 schools and 16 clinics) and were repeated 2-6 weeks after the campaign, in November 2018. Single-dose sulfadoxine-pyrimethamine and primaquine was used for MDA, and pirimiphos-methyl as insecticide for IRS.Results: A total of 10 006 participants were recruited. Fifty-two percent of the population in the intervention area reported having received MDA. Prevalence diminished between 2017 and 2018 in both areas, but the reduction was significantly larger in the intervention area (ratio of adjusted risk ratios, 0.32 [95% confidence interval, .104-.998]).Conclusions: Despite a moderate coverage, the campaign was effective in reducing P. falciparum prevalence immediately after 1 round. Targeted MDA plus IRS is useful in preelimination settings to rapidly decrease the parasite reservoir, an encouraging step to accelerate progress toward malaria elimination. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder