التفاصيل البيبلوغرافية
| العنوان: |
The Role of MiR-181 Family Members in Endothelial Cell Dysfunction and Tumor Angiogenesis. |
| المؤلفون: |
Yang, Chun, Passos Gibson, Victor, Hardy, Pierre |
| المصدر: |
Cells (2073-4409); May2022, Vol. 11 Issue 10, p1670-N.PAG, 18p |
| مصطلحات موضوعية: |
ENDOTHELIUM diseases, NEOVASCULARIZATION inhibitors, CANCER cells, GENE expression, ENDOTHELIAL cells, CELLULAR signal transduction |
| مستخلص: |
Endothelial dysfunction plays a critical role in many human angiogenesis-related diseases, including cancer and retinopathies. Small non-coding microRNAs (miRNAs) repress gene expression at the post-transcriptional level. They are critical for endothelial cell gene expression and function and are involved in many pathophysiological processes. The miR-181 family is one of the essential angiogenic regulators. This review summarizes the current state of knowledge of the role of miR-181 family members in endothelial cell dysfunction, with emphasis on their pathophysiological roles in aberrant angiogenesis. The actions of miR-181 members are summarized concerning their targets and associated major angiogenic signaling pathways in a cancer-specific context. Elucidating the underlying functional mechanisms of miR-181 family members that are dysregulated in endothelial cells or cancer cells is invaluable for developing miRNA-based therapeutics for angiogenesis-related diseases such as retinopathies, angiogenic tumors, and cancer. Finally, potential clinical applications of miR-181 family members in anti-angiogenic tumor therapy are discussed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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