التفاصيل البيبلوغرافية
العنوان: |
The Role of MiR-181 Family Members in Endothelial Cell Dysfunction and Tumor Angiogenesis. |
المؤلفون: |
Yang, Chun, Passos Gibson, Victor, Hardy, Pierre |
المصدر: |
Cells (2073-4409); May2022, Vol. 11 Issue 10, p1670-N.PAG, 18p |
مصطلحات موضوعية: |
ENDOTHELIUM diseases, NEOVASCULARIZATION inhibitors, CANCER cells, GENE expression, ENDOTHELIAL cells, CELLULAR signal transduction |
مستخلص: |
Endothelial dysfunction plays a critical role in many human angiogenesis-related diseases, including cancer and retinopathies. Small non-coding microRNAs (miRNAs) repress gene expression at the post-transcriptional level. They are critical for endothelial cell gene expression and function and are involved in many pathophysiological processes. The miR-181 family is one of the essential angiogenic regulators. This review summarizes the current state of knowledge of the role of miR-181 family members in endothelial cell dysfunction, with emphasis on their pathophysiological roles in aberrant angiogenesis. The actions of miR-181 members are summarized concerning their targets and associated major angiogenic signaling pathways in a cancer-specific context. Elucidating the underlying functional mechanisms of miR-181 family members that are dysregulated in endothelial cells or cancer cells is invaluable for developing miRNA-based therapeutics for angiogenesis-related diseases such as retinopathies, angiogenic tumors, and cancer. Finally, potential clinical applications of miR-181 family members in anti-angiogenic tumor therapy are discussed. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cells (2073-4409) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |