التفاصيل البيبلوغرافية
| العنوان: |
التقدير الطيفي غير المباشر للكارفيديلول وهيدروكلوريد البروبرانولول بشكلهما النقي باستخدام صبغة المثيل البرتقالي والتطبيق على مستحضراتهما الدوائية. (Arabic) |
| Alternate Title: |
Indirect Spectroscopic Determination of Carvedilol and Propranolol Hydrochloride in Its Pure Form Using Methyl Orange Dye and Applying to Their Pharmaceutical Preparations. (English) |
| المؤلفون: |
داؤد حبو محمد, احالم احمد شهاب |
| المصدر: |
College of Basic Education Researches Journal; 2022, Vol. 18 Issue 1, p996-1029, 34p |
| مصطلحات موضوعية: |
DRUGS, PINK, OXIDIZING agents, PROPRANOLOL, CARVEDILOL |
| Abstract (English): |
An easy, rapid, and indirect, selective spectroscopic method was developed for estimating Carvedilol and Propranolol in their pure form and in their pharmaceutical preparations, as the method relies on oxidation and reduction with a known increase (excess) of the oxidizing agent cerium sulfate ( in medium of sulfuric acid 5 molar) and estimation of the remaining of the oxidizing agent (surplus excess) by its reaction with methyl orange to form a pink color complex, the maximum absorption was given at the wavelength of 507 nm. The relationship was linear with in the ranges of concentration (0.5 - 24.5 and 0.5 - 24.0) μg / ml for carvedilol and propranolol respectively with molar absorptivity of 2.88 × 104 and 2.076 x 104 l. mol-1 . cm-1 and recovery rate of 99.54% and 99.42% respectively standard deviation value amounted to less than 0.37% for each one of the Carvedilol and Propranolol respectively in such a way that indicates good accuracy and compatibility. The method was successfully applied to the pharmaceutical preparations of the two drugs under study on the form of tablets, The results of the method are compatible with the original content of the pharmaceutical preparations and with the results of the standard addition method, there is no noticeable overlap of the excipient materials, that proves the efficiency of the proposed method. [ABSTRACT FROM AUTHOR] |
| Abstract (Arabic): |
طورت طريقة انتقائيةة هةة،ةس هةريوة ر مةر رةالةرد رتقة ر Carvedilol و Propranolol فة لةه،ة ا اريقة رفةة رضتاتةةرالة ا ارةةةم تنية عات ت ةةا ،ةةا امعضةة د راتوتةةزائ رةةن ايةةا د روررفةةة اائةة د رةة اروارةة ار ضةة عبريتةةات ارضةةمريوس رهة لةةارت ار بريتيةة 5 رةوتر رلقة ر رةا لةقةا رة اروارة ار ضة ار ةائت رة وةة ئ ارت ا رن ار مثم اربرلقار رت وي رر ب رر ار،ونس أ طمت اقةا ارتةاص عطوئ روج 507 نانورتر. انت ارو قة وطية ف نطاقات ارتر مز 5.0- 5.24 ر5.0- 0.24 رةاكهرر راس رة ر، ارفمة ،وئ راربررنرانورةوئ ،ةا 4 ارتةوار س راترتةايةية ار وريةة ر 2.88 x 10 4 رةوئ. رتةر 2.076 x 10 -1 . هة -1 رروة ئ اتهةترجا 54.99 ٪ر 42.99، ٪ةةا ارتةةوار س رن،ةةةت ري ةةة اتناةةران ار ياهةة أقةة رةة 37.0 ٪ر ةة رةة ارفمةة ،وئ رنررنرانورةةوئ ،ةةا ارتةةوار . لرةةمر ارطريقةة درةةا ار قةةة رارتوافةت ارقمةة . رلةة لطبيقةةةا يقةةاال ،ةةا ار ضتاتةةرات ارةةةم تنية ر،وقةاري قمةة ار راهة ،ا له أقراص س نتائج ارطريقة رتوافقةة رةن ار اتةو ى امية، ر، ضتاتة ارت ارةةم تنية ررةن نتةائج طريقةة اتضافة ار ياهية ار ياهية س ا انه ت وج ل او ر،اوظ ر، وا ارضواغ ر ا ثبت اءد ارطريقة ار قترلة. [ABSTRACT FROM AUTHOR] |
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