التفاصيل البيبلوغرافية
| العنوان: |
Factors Associated with Post-Acute Sequelae of SARS-CoV-2 (PASC) After Diagnosis of Symptomatic COVID-19 in the Inpatient and Outpatient Setting in a Diverse Cohort. |
| المؤلفون: |
Yoo, Sun M., Liu, Teresa C., Motwani, Yash, Sim, Myung S., Viswanathan, Nisha, Samras, Nathan, Hsu, Felicia, Wenger, Neil S. |
| المصدر: |
JGIM: Journal of General Internal Medicine; 2022 Supplement, Vol. 37, p1988-1995, 8p, 1 Diagram, 2 Charts, 1 Graph |
| مستخلص: |
Background: The incidence of persistent clinical symptoms and risk factors in Post-Acute Sequelae of SARS-CoV-2 (PASC) in diverse US cohorts is unclear. While there are a disproportionate share of COVID-19 deaths in older patients, ethnic minorities, and socially disadvantaged populations in the USA, little information is available on the association of these factors and PASC.Objective: To evaluate the association of demographic and clinical characteristics with development of PASC.Design: Prospective observational cohort of hospitalized and high-risk outpatients, April 2020 to February 2021.Participants: One thousand thirty-eight adults with laboratory-confirmed symptomatic COVID-19 infection.Main Measures: Development of PASC determined by patient report of persistent symptoms on questionnaires conducted 60 or 90 days after COVID-19 infection or hospital discharge. Demographic and clinical factors associated with PASC.Key Results: Of 1,038 patients with longitudinal follow-up, 309 patients (29.8%) developed PASC. The most common persistent symptom was fatigue (31.4%) followed by shortness of breath (15.4%) in hospitalized patients and anosmia (15.9%) in outpatients. Hospitalization for COVID-19 (odds ratio [OR] 1.49, 95% [CI] 1.04-2.14), having diabetes (OR, 1.39; 95% CI 1.02-1.88), and higher BMI (OR, 1.02; 95% CI 1-1.04) were independently associated with PASC. Medicaid compared to commercial insurance (OR, 0.49; 95% CI 0.31-0.77) and having had an organ transplant (OR 0.44, 95% CI, 0.26-0.76) were inversely associated with PASC. Age, race/ethnicity, Social Vulnerability Index, and baseline functional status were not associated with developing PASC.Conclusions: Three in ten survivors with COVID-19 developed a subset of symptoms associated with PASC in our cohort. While ethnic minorities, older age, and social disadvantage are associated with worse acute COVID-19 infection and greater risk of death, our study found no association between these factors and PASC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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