التفاصيل البيبلوغرافية
| العنوان: |
Reproductive factors and gall-bladder cancer, and the effect of common genetic variants on these associations: a case-control study in India. |
| المؤلفون: |
Mhatre, Sharayu, Lacey, Ben, Sherliker, Paul, Chatterjee, Nilanjan, Rajaraman, Preetha, Goel, Mahesh, Patkar, Shraddha, Ostwal, Vikas, Patil, Prachi, Shrikhande, Shailesh V, Chitkara, Garvit, Badwe, Rajendra, Lewington, Sarah, Dikshit, Rajesh |
| المصدر: |
International Journal of Epidemiology; Jun2022, Vol. 51 Issue 3, p789-798, 10p |
| مصطلحات موضوعية: |
BLADDER tumors, CASE-control method, MENARCHE, PARITY (Obstetrics), RESEARCH funding, MENOPAUSE, REPRODUCTIVE history |
| مستخلص: |
Background: In India, as elsewhere, the incidence of gall-bladder cancer (GBC) is substantially higher in women than in men. Yet, the relevance of reproductive factors to GBC remains poorly understood.Methods: We used logistic regression adjusted for age, education and area to examine associations between reproductive factors and GBC risk, using 790 cases of histologically confirmed GBC and group-matched 1726 visitor controls. We tested the interaction of these associations by genetic variants known to increase the risk of GBC.Results: Parity was strongly positively associated with GBC risk: each additional pregnancy was associated with an ∼25% higher risk {odds ratio [OR] 1.26 [95% confidence interval (95% CI) 1.17-1.37]}. After controlling for parity, GBC risk was weakly positively associated with later age of menarche [postmenopausal women, OR 1.11 (95% CI 1.00-1.22) per year], earlier menopause [OR 1.03 (95% CI 1.00-1.06) per year] and shorter reproductive lifespan [OR 1.04 (95% CI 1.01-1.07) per year], but there was little evidence of an association with breastfeeding duration or years since last pregnancy. Risk alleles of single-nucleotide polymorphisms in the ABCB4 and ABCB1 genetic regions had a multiplicative effect on the association with parity, but did not interact with other reproductive factors.Conclusions: We observed higher GBC risk with higher parity and shorter reproductive lifespan, suggesting an important role for reproductive and hormonal factors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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