التفاصيل البيبلوغرافية
| العنوان: |
Sulfation of chitosan from Sepia kobiensis as potential anticoagulant and antibacterial molecule. |
| المؤلفون: |
Ramasamy, Pasiyappazham, Sekar, Sivasankari, Paramasivam, Sivagurunathan, Suri, Priyatharsini, Chinnaiyan, Uma, Singh, Rajesh, Tanguturi Raghavaiah, Bharath Prasad, Seshadri, Vidya Devanathadesikan |
| المصدر: |
Natural Product Research; Jun2022, Vol. 36 Issue 12, p3216-3222, 7p |
| مصطلحات موضوعية: |
CHITOSAN, SULFATION, PARTIAL thromboplastin time, RODENTICIDES |
| مستخلص: |
The present work aimed to synthesis of chitin, chitosan and sulfation of chitosan from cuttlebone of cuttlefish Sepia kobiensis. Principally chitin was extracted through sequential processes of demineralisation and deproteinzation. Then chitosan was synthesized by a deacetylation and finally sulfated at semi-heterogeneous condition using chlorosulfonic acid in N,N-dimethylformamide. The synthesized macromolecules were characterized for its structural, physical and thermal (CHN, DDA, FT-IR, NMR, XRD, Viscometric analysis, SEM and DSC) properties. Apart from anticoagulant potential of the sulfated chitosan was tested using human plasma by means of activated partial thromboplastin time (APTT) and prothrombin time (PT). Further sulfated chitosan was tested for antibacterial potential by well diffusion method against eleven human pathogenic clinical isolates of both Gram positive and Gram-negative strains and minimum inhibitory concentrations (MIC) was calculated accordingly. The results of this study revealed the effectiveness of the sulfated chitosan at semi-heterogeneous conditions as a potent antibacterial and anticoagulant molecule. [ABSTRACT FROM AUTHOR] |
|
Copyright of Natural Product Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher 
Full Text Finder