التفاصيل البيبلوغرافية
| العنوان: |
Anthocyanin-Rich Blackcurrant Extract Preserves Gastrointestinal Barrier Permeability and Reduces Enterocyte Damage but Has No Effect on Microbial Translocation and Inflammation After Exertional Heat Stress. |
| المؤلفون: |
Lee, Ben J., Flood, Tessa R., Hiles, Ania M., Walker, Ella F., Wheeler, Lucy E.V., Ashdown, Kimberly M., Willems, Mark E.T., Costello, Rianne, Greisler, Luke D., Romano, Phebe A., Hill, Garrett W., Kuennen, Matthew R. |
| المصدر: |
International Journal of Sport Nutrition & Exercise Metabolism; Jul2022, Vol. 32 Issue 4, p265-274, 10p, 1 Chart, 4 Graphs |
| مصطلحات موضوعية: |
LIPOPOLYSACCHARIDES, INTERLEUKINS, FLAVONOIDS, CONFIDENCE intervals, PHYSIOLOGICAL effects of heat, INFLAMMATION, PERMEABILITY, FATTY acid-binding proteins, BLOOD collection, TREATMENT effectiveness, DIETARY supplements, RANDOMIZED controlled trials, SMALL intestine, DESCRIPTIVE statistics, BLIND experiment, PLANT extracts, EPITHELIAL cells, STATISTICAL sampling, CROSSOVER trials, DEOXY sugars, DISACCHARIDES, EVALUATION |
| مستخلص: |
This study investigated the effects of 7 days of 600 mg/day anthocyanin-rich blackcurrant extract intake on small intestinal permeability, enterocyte damage, microbial translocation, and inflammation following exertional heat stress. Twelve recreationally active men (maximal aerobic capacity = 55.6 ± 6.0 ml·kg−1·min−1) ran (70% VO2max) for 60 min in an environmental chamber (34 °C, 40% relative humidity) on two occasions (placebo/blackcurrant, randomized double-blind crossover). Permeability was assessed from a 4-hr urinary excretion of lactulose and rhamnose and expressed as a ratio of lactulose/rhamnose. Venous blood samples were taken at rest and 20, 60, and 240 min after exercise to measure enterocyte damage (intestinal fatty acid-binding protein); microbial translocation (soluble CD14, lipopolysaccharide-binding protein); and interleukins 6, interleukins 10, and interleukins 1 receptor antagonist. Exercise increased rectal temperature (by ∼2.8 °C) and heart rate (by ∼123 beats/min) in each condition. Blackcurrant supplementation led to a ∼12% reduction in lactulose/rhamnose ratio (p <.0034) and enterocyte damage (∼40% reduction in intestinal fatty acid-binding protein area under the curve; p <.0001) relative to placebo. No between-condition differences were observed immediately after exercise for lipopolysaccharide-binding protein (mean, 95% confidence interval [CI]; +80%, 95% CI [+61%, +99%]); soluble CD14 (+37%, 95% CI [+22%, +51%]); interleukins 6 (+494%, 95% CI [+394%, +690%]); interleukins 10 (+288%, 95% CI [+105%, +470%]); or interleukins 1 receptor antagonist (+47%, 95% CI [+13%, +80%]; all time main effects). No between-condition differences for these markers were observed after 60 or 240 min of recovery. Blackcurrant extract preserves the GI barrier; however, at subclinical levels, this had no effect on microbial translocation and downstream inflammatory processes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
