التفاصيل البيبلوغرافية
| العنوان: |
Corelaţia dintre fragilitate și ateroscleroza subclinică la pacienţii vârstnici. (Romanian) |
| Alternate Title: |
Correlation between frailty and suclinical atheroscleosis in elderly patients. (English) |
| المؤلفون: |
Mihalache, Ruxandra, Aurelian, Sorina-Maria, Capisizu, Ana |
| المصدر: |
Romanian Journal of Family Medicine / Revista Română de Medicina Familiei; Jun2022, Vol. 5 Issue 2, p5-8, 4p |
| مصطلحات موضوعية: |
CAROTID intima-media thickness, INFORMED consent (Medical law), ATHEROSCLEROTIC plaque, MINI-Mental State Examination, OLDER patients |
| Abstract (English): |
Introduction: Frailty is frequently associated with cumulative functional decline resulting in depletion of biological reserve and increased incidence of falls, disability, repeated and prolonged hospitalizations or high mortality. Purpose: This study analyses the correlation between frailty and subclinical atherosclerosis expressed by arterial vascular, biological changes or cognitive impairment in the elderly. Material and methods: A cross-sectional study was conducted over a 12-month period on a group of 139 patients with a mean age of 73±6.8 years. Lipid profile, intima-media thickness (IMT) and atherosclerotic plaques (carotid ultrasound), frailty (Fried scale) and cognitive status (Mini-Mental State Examination) were analysed. All patients signed informed consent and statistical analysis was performed using IBM SPSS-2018. Results: Lipid profile classifies the group in hyperlipidaemic status by the presence of hypertriglyceridemia (TG=158±69.8 mg/dl). We used the plasma atherogenic index [AIP=log (TG/HDL)] to analyse the impact of lipid molecules on atherosclerosis and frailty. The 139 subjects were divided into three subgroups according to their Fried scale scores: non-frail (11.5%), pre-frail (32.4%) and frail (56.1%). AIP had a statistically significant correlation (p=0.001), with an increase of ~20% for the frail group. A direct correlation was obtained between frailty and IMT values with a mean value of 1.3±0.29mm. The frail subgroup 84.4% of the patients had carotid plaques (p<0.001). Cognitive impairment was statistically significant correlated with frailty (p=0.024). Conclusions: Cardiovascular disease, atherosclerosis and frailty are intercorrelated in elderly patients. Cognitive impairment is a risk factor for frailty and prior detection of cognitive impairment may benefit from targeted interventions, for example: maintaining an adequate lipid profile, screening assessment of carotid IMT in pre-frail elderly adults. [ABSTRACT FROM AUTHOR] |
| Abstract (Romanian): |
Introducere: Fragilitatea este frecvent asociată cu un declin funcţional cumulativ care are drept consecinţă epuizarea rezervei biologice şi incidenţa crescută a căderilor, a dizabilităţii, a spitalizărilor repetate şi prelungite sau o mortalitate ridicată. Scop: Analiza corelaţiilor dintre fragilitate şi ateroscleroza subclinică exprimată prin modificări vasculare arteriale, biologice sau afectare cognitivă la persoanele vârstnice. Material şi metode: S-a realizat un studiu transversal, pe o perioadă de 12 luni, asupra unui lot de 139 pacienţi cu vârsta medie de 73±6,8 ani. S-a analizat profilul lipidic, grosimea intimă medie (IMT) i plăcile de aterom (ultrasonografie carotidiană), fragilitatea (scala Fried) i statusul cognitiv (Mini-Mental State Examination). Toi pacienii au semnat consimământul informat şi analiza statistică s-a realizat prin IBM SPSS-2018. Rezultate: Profilul lipidic clasifică lotul în status hiperlipidemic prin prezena hipertrigliceridemiei (TG=158±69.8 mg/dl). Am utilizat indexul aterogenic plasmatic [AIP=log(TG/HDL)] pentru analiza impactului profilului lipidic asupra aterosclerozei şi a fragilităţii. Cei 139 de subiecţi au fost împărţiţi în trei subloturi în funcie de scorurile obinute la scala Fried: non-fragili (11.5%), prefragili (32.4%) şi fragili (56.1%). AIP are o corelaţie statistic semnificativă (p=0.001), cu o creştere de ~20% pentru grupul fragil. S-a obinut o corelaie directă între fragilitate i valorile IMT cu valoarea medie de 1.3±0.29mm. Sublotul fragil are o proporie de 84.4% de pacieni cu plăci carotidiene, având corelaţie directă cu semnificaie statistică (p<0.001). Deficitul cognitiv are o corelaţie pozitivă semnificativ statistică (p=0.024) cu fragilitatea. Concluzii: Bolile cardiovasculare, ateroscleroza fragilitatea sunt în corelaie directă la pacienii vârstnici. Deficitul cognitiv este factor de risc pentru fragilitate i depistarea precoce a stadiilor incipiente poate aduce beneficii prin intervenii specifice, de exemplu: meninerea unui profil lipidic adecvat, evaluarea tip screening a IMT carotidian la adulţii vârstnici prefragili. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
