التفاصيل البيبلوغرافية
| العنوان: |
Analysis of the mechanism of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure based on network pharmacology. |
| المؤلفون: |
Mei-Hui Chen, Yu-Bo Han, Yan-Bo Sui, Li Liu |
| المصدر: |
Journal of Hainan Medical University; May2022, Vol. 28 Issue 9, p41-47, 7p |
| مصطلحات موضوعية: |
HEART failure, PHARMACOLOGY, PROTEIN-protein interactions, DRUG target, CELLULAR signal transduction |
| مستخلص: |
Objective: To explore and analyze the effective component, target and mechanism of action of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure (CHF) by network pharmacological research methods. Methods: With the help of TCMSP database, the effective chemical constituents and targets of Radix Astragali-Radix Pseudostellariae were screened out, and CHF-related proteins were obtained by Gene Cards and OMIM database. The target protein interaction network (PPI) was constructed on the String database platform, and using DAVID database to conduct the GO function and KEGG pathway enrichment analysis on the target of the obtained astragalus-pseudostellariae for the treatment of CHF. Results: Radix Astragali-Radix Pseudostellariae were selected as 28 effective chemical components and 104 therapeutic targets for CHF. There were obtained 49 GO functional annotations and 86 KEGG signaling pathways. Conclusion: Radix Astragali-Radix Pseudostellariae can treat CHF through multi-target and multi-pathway. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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