التفاصيل البيبلوغرافية
| العنوان: |
Influenza A-Associated In-Hospital Mortality in Very Older People: Does Inflammation Also Play a Role? |
| المؤلفون: |
Arrieta, Estibaliz, Lalueza, Antonio, Ayuso-García, Blanca, Trujillo, Hernando, Folgueira, Dolores, Paredes, Diana, Verdejo, Miguel Ángel, Camacho, Javier, Caso, José María, Heredia, Carlos, Cueto-Felgueroso, Cecilia, Pleguezuelo, Daniel, Serrano, Antonio, Lumbreras, Carlos |
| المصدر: |
Gerontology; 2022, Vol. 68 Issue 7, p780-788, 9p |
| مستخلص: |
Background: The aim of the study was to analyze the clinical manifestations and outcome of the oldest old (people aged ≥85 years) who were admitted to the hospital with a confirmed influenza A virus infection in comparison with younger patients and to assess the role of inflammation in the outcome of influenza infection in this population. Methods: This is an observational prospective study including all adult patients with influenza A virus infection hospitalized in a tertiary teaching hospital in Madrid, in 2 consecutive influenza seasons (2016–17 and 2017–18). Results: Five hundred nine hospitalized patients with influenza A infection were included, of whom 117 (23%) were older than 85 years (median age: 89.3 ± 3.2). We compared the clinical characteristics and outcome with those of the rest of the population (median age: 72.8 ± 15.7). Overall, mortality was higher in older patients (10% vs. 4%; p = 0.03) with no differences in clinical presentation. Patients older than 85 years who ultimately died (12 out of 117) showed increased systemic inflammation expressed by higher levels of C-reactive protein (CRP) and ferritin compared to survivors who were discharged (odds ratio [OR] of CRP >20 mg/dL: 5.16, 95% confidence interval [CI]: 1.29–20.57, and OR of ferritin >500 mg: 4.3, 95% CI: 1.04–17.35). Conclusions: Patients aged 85 and older with influenza A virus infection presented a higher in-hospital mortality than younger subjects. CRP and ferritin levels were higher in the oldest old who died, suggesting that inflammation could play a key role in the outcome of this subset of patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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