التفاصيل البيبلوغرافية
العنوان: |
Insights into the modulation of the interferon response and NAD+ in the context of COVID-19. |
المؤلفون: |
Habeichi, Nada J., Tannous, Cynthia, Yabluchanskiy, Andriy, Altara, Raffaele, Mericskay, Mathias, Booz, George W., Zouein, Fouad A. |
المصدر: |
International Reviews of Immunology; 2022, Vol. 41 Issue 4, p464-474, 11p |
مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, INTERFERONS |
مستخلص: |
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in dramatic worldwide mortality. Along with developing vaccines, the medical profession is exploring new strategies to curb this pandemic. A better understanding of the molecular consequences of SARS-CoV-2 cellular infection could lead to more effective and safer treatments. This review discusses the potential underlying impact of SARS-CoV-2 in modulating interferon (IFN) secretion and in causing mitochondrial NAD+ depletion that could be directly linked to COVID-19's deadly manifestations. What is known or surmised about an imbalanced innate immune response and mitochondrial dysfunction post-SARS-CoV-2 infection, and the potential benefits of well-timed IFN treatments and NAD+ boosting therapies in the context of the COVID-19 pandemic are discussed. [ABSTRACT FROM AUTHOR] |
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قاعدة البيانات: |
Complementary Index |