دورية أكاديمية
Insights into the modulation of the interferon response and NAD+ in the context of COVID-19.
| العنوان: | Insights into the modulation of the interferon response and NAD+ in the context of COVID-19. |
|---|---|
| المؤلفون: | Habeichi, Nada J., Tannous, Cynthia, Yabluchanskiy, Andriy, Altara, Raffaele, Mericskay, Mathias, Booz, George W., Zouein, Fouad A. |
| المصدر: | International Reviews of Immunology; 2022, Vol. 41 Issue 4, p464-474, 11p |
| مصطلحات موضوعية: | SARS-CoV-2, COVID-19, INTERFERONS |
| مستخلص: | The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in dramatic worldwide mortality. Along with developing vaccines, the medical profession is exploring new strategies to curb this pandemic. A better understanding of the molecular consequences of SARS-CoV-2 cellular infection could lead to more effective and safer treatments. This review discusses the potential underlying impact of SARS-CoV-2 in modulating interferon (IFN) secretion and in causing mitochondrial NAD+ depletion that could be directly linked to COVID-19's deadly manifestations. What is known or surmised about an imbalanced innate immune response and mitochondrial dysfunction post-SARS-CoV-2 infection, and the potential benefits of well-timed IFN treatments and NAD+ boosting therapies in the context of the COVID-19 pandemic are discussed. [ABSTRACT FROM AUTHOR] |
| Copyright of International Reviews of Immunology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
PDF full text from Publisher كن أول من يترك تعليقا!