التفاصيل البيبلوغرافية
| العنوان: |
Altered mucosal immunity in HIV-positive colon adenoma: decreased CD4+ T cell infiltration is correlated with nadir but not current CD4+ T cell blood counts. |
| المؤلفون: |
Matsubara, Yasuo, Ota, Yasunori, Tanaka, Yukihisa, Denda, Tamami, Hijikata, Yasuki, Boku, Narikazu, Lim, Lay Ahyoung, Hirata, Yoshihiro, Tsurita, Giichiro, Adachi, Eisuke, Yotsuyanagi, Hiroshi |
| المصدر: |
International Journal of Clinical Oncology; Aug2022, Vol. 27 Issue 8, p1321-1330, 10p |
| مصطلحات موضوعية: |
BLOOD cell count, T cells, IMMUNE checkpoint proteins, COLON polyps, COLON (Anatomy), HIV-positive persons, ADENOMATOUS polyps |
| مستخلص: |
Background: People living with HIV (PLWH) face greater risks of developing non-AIDS-defining cancers (NADCs) than the general population; however, the underlying mechanisms remain elusive. The tumor microenvironment plays a significant role in the carcinogenesis of colorectal cancer (CRC), an NADC. We studied this carcinogenesis in PLWH by determining inflammatory phenotypes and assessing PD-1/PD-L1 expression in premalignant CRC stages of colon adenomas in HIV-positive and HIV-negative patients. Methods: We obtained polyp specimens from 22 HIV-positive and 61 HIV-negative participants treated with colonoscopy and polyp excision. We analyzed adenomas from 33 HIV-positive and 99 HIV-negative patients by immunohistochemistry using anti-CD4, anti-CD8, anti-FoxP3, and anti-CD163 antibodies. Additionally, we analyzed the expression levels of immune checkpoint proteins. We also evaluated the correlation between cell infiltration and blood cell counts. Results: HIV-positive participants had fewer infiltrating CD4+ T cells than HIV-negative participants (p = 0.0016). However, no statistical differences were observed in infiltrating CD8+ and FoxP3+ T cells and CD163+ macrophages. Moreover, epithelial cells did not express PD-1 or PD-L1. Notably, CD4+ T cell infiltration correlated with nadir blood CD4+ T cell counts (p < 0.05) but not with current blood CD4+ T cell counts. Conclusion: Immune surveillance dysfunction owing to decreased CD4+ T cell infiltration in colon adenomas might be involved in colon carcinogenesis in HIV-positive individuals. Collectively, since the nadir blood CD4+ T cell count is strongly correlated with CD4+ T cell infiltration, it could facilitate efficient follow-up and enable treatment strategies for HIV-positive patients with colon adenomas. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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