التفاصيل البيبلوغرافية
| العنوان: |
Controlled delivery of tetracycline with TiO2@Chitosan@ZIF-8 nanocomposite and evaluation of their antimicrobial activities. |
| المؤلفون: |
Akbari, Mahdiyeh, Sadeghi, Mohammad Emad, Ghasemzadeh, Mohammad Ali |
| المصدر: |
Research on Chemical Intermediates; Sep2022, Vol. 48 Issue 9, p3971-3985, 15p |
| مصطلحات موضوعية: |
TETRACYCLINES, TETRACYCLINE, ANTI-infective agents, FIELD emission electron microscopes, THERMOGRAVIMETRY, ESCHERICHIA coli, X-ray crystallography |
| مستخلص: |
In recent years, metal–organic frameworks (MOFs) have attracted the attention of scientists. The applications of these frameworks are gas storage and separation, electrochemical energy storage, drug delivery, catalyst, etc. In this research, a nanocarrier named TiO2@Chitosan@ZIF-8 was synthesized to deliver the antibiotic tetracycline (TC). Furthermore, the antimicrobial effect of TiO2@Chitosan@ZIF-8@TC was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria with the best results. The structure of the nanocarrier, as well as the nanocarrier/drug, was validated by the X-ray crystallography (XRD), Fourier-transform infrared spectroscopy (FT-IR), Breuer–Emmett–Teller (BET), field emission scanning electron microscope (FE-SEM), Transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and energy-dispersive X-ray spectroscopy (EDX/Mapping). This research indicated that 90% of the TC was encapsulated in the synthesized framework. Also, drug release was performed at pH: 5 and pH: 7.4, which revealed that 73% and 67% of TC were released in three days. It is considerable that this is the first report of the synthesizing and using a novel nanocarrier including TiO2@Chitosan@ZIF-8 with various advantages such as high surface area, high porosity, high loading percentage, and high stability. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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