التفاصيل البيبلوغرافية
| العنوان: |
Characterization of the Notch pathway in nasal polyps of patients with chronic rhinosinusitis: A pilot study. |
| المؤلفون: |
Aquila, Giorgio, Alaimo, Alessandra, Marracino, Luisa, Martino, Valeria, Camponogara, Francesca, Vieceli Dalla Sega, Francesco, Fortini, Francesca, Pannuti, Antonio, Zanotti, Claudia, Malagutti, Nicola, Pelucchi, Stefano, Rizzo, Paola |
| المصدر: |
Physiological Reports; Aug2022, Vol. 10 Issue 16, p1-11, 11p |
| مصطلحات موضوعية: |
NASAL polyps, RHINITIS, SINUSITIS, NOTCH genes, PILOT projects, GENE expression |
| مستخلص: |
Chronic rhinosinusitis with nasal polyps is a widespread pathology characterized by persistent inflammation of nasal and paranasal mucosa. Although it represents one of the most frequent diseases of the nasal cavities, its etiology is still not completely elucidated. There is evidence suggesting that the Notch signaling, a highly conserved intercellular pathway known to regulate many cellular processes, including inflammation, is implicated in nasal polyps formation. The purpose of this study was to investigate the expression of genes of the Notch pathway in nasal polyps from patients with chronic rhinosinusitis. Nasal polyps and adjacent mucosa tissue were obtained from 10 patients. RNA was analyzed by quantitative reverse transcriptase‐polymerase chain reaction for the expression level of (1) Notch pathway components such as receptors (NOTCH1‐4), ligands (DLL4, JAGGED‐1), and target genes (HEY1, 2, and HES1) and (2) genes providing information on the pathogenesis of polyposis (C‐MYC and SCGB1A1) and on eosinophils content (CCL26, IL5, and SAA2). We report a Notch‐driven gene expression pattern in nasal polyps which correlates with the expression of genes highly expressed in eosinophils, whose presence is an important parameter to define the pathophysiologic diversity characterizing nasal polyps. Taken together, our results suggest a role for Notch signaling in the pathophysiology of polyposis. Further studies are needed to elucidate the role of Notch in nasal polyps formation and to establish whether it could represent a novel therapeutic target for this pathology. [ABSTRACT FROM AUTHOR] |
|
Copyright of Physiological Reports is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder