التفاصيل البيبلوغرافية
| العنوان: |
NF-кB c-Rel modulates pre-fibrotic changes in human fibroblasts. |
| المؤلفون: |
Micus, Lara Carolina, Trautschold-Krause, Franziska Susanne, Jelit, Anna Lena, Schön, Michael Peter, Lorenz, Verena Natalie |
| المصدر: |
Archives of Dermatological Research; Dec2022, Vol. 314 Issue 10, p943-951, 9p |
| مصطلحات موضوعية: |
EXTRACELLULAR matrix proteins, SYSTEMIC scleroderma, FIBROBLASTS, AUTOIMMUNE diseases, TRANSCRIPTION factors |
| مستخلص: |
Skin fibrosis is one central hallmark of the heterogeneous autoimmune disease systemic sclerosis. So far, there are hardly any standardized and effective treatment options. Pathogenic mechanisms underlying fibrosis comprise excessive and uncontrolled myofibroblast differentiation, increased extracellular matrix protein (ECM) synthesis and an intensification of the forces exerted by the cytoskeleton. A deeper understanding of fibroblast transformation could help to prevent or reverse fibrosis by specifically interfering with abnormally regulated signaling pathways. The transcription factor NF-κB has been implicated in the progression of fibrotic processes. However, the cellular processes regulated by NF-κB in fibrosis as well as the NF-κB isoforms preferentially involved are still completely unknown. In an in vitro model of fibrosis, we consistently observed the induction of the c-Rel subunit of NF-κB. Functional abrogation of c-Rel by siRNA resulted in diminished cell contractility of dermal fibroblasts in relaxed, but not in stressed 3D collagen matrices. Furthermore, directed migration was reduced after c-Rel silencing and total N-cadherin expression level was diminished, possibly mediating the observed cellular defects. Therefore, NF-кB c-Rel impacts central cellular adhesion markers and processes which negatively regulate fibrotic progression in SSc pathophysiology. [ABSTRACT FROM AUTHOR] |
|
Copyright of Archives of Dermatological Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder