التفاصيل البيبلوغرافية
| العنوان: |
Topical Application of Houttuynia cordata Thunb Ethanol Extracts Increases Tumor Infiltrating CD8+/Treg Cells Ratio and Inhibits Cutaneous Squamous Cell Carcinoma in vivo. |
| المؤلفون: |
Lipeng Gao, Rongyin Gui, Xinnan Zheng, Yingxue Wang, Yao Gong, Tim Hua Wang, Jichuang Wang, Junyi Huang, Xinhua Liao |
| المصدر: |
Oncologie (Tech Science Press); 2022, Vol. 24 Issue 3, p565-577, 13p |
| مصطلحات موضوعية: |
TOPICAL drug administration, SQUAMOUS cell carcinoma, TUMOR-infiltrating immune cells, REGULATORY T cells, TUMOR growth |
| مستخلص: |
Houttuynia cordata Thunb (HCT) is a medicinal and edible herb that has beneficial effects on various diseases due to its diuretic, anti-inflammatory, anti-oxidative, anti-microbial, anti-viral, anti-cancer and anti-diabetic properties. Most reports of its anti-cancer activity were conducted in vitro, and its effects on cutaneous squamous cell carcinoma (SCC) have not been investigated yet. Using DMBA/TPA induced SCC mice model, we found that topical treatment by HCT, as well as its bioactive ingredient monomer, efficiently inhibited tumor growth. Mechanistically, tumor infiltrating CD4+, Foxp3+ T regulatory cells (Tregs) were significantly reduced and CD8+/Treg cells ratio was largely increased in tumors after HCT treatment. In addition, several chemokines which function to recruit immune cells were largely reduced in SCC cancer cells treated by HCT in vitro. Our results demonstrate the therapeutic effects of HCT on cutaneous SCC and indicate it might inhibit cancer through regulating tumor infiltrating lymphocytes and the tumor immune microenvironments. [ABSTRACT FROM AUTHOR] |
|
Copyright of Oncologie (Tech Science Press) is the property of Tech Science Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag.