التفاصيل البيبلوغرافية
| العنوان: |
Effects of RAGE Deletion on the Cardiac Transcriptome during Aging. |
| المؤلفون: |
Scavello, Francesco, Piacentini, Luca, Castiglione, Stefania, Zeni, Filippo, Macrì, Federica, Casaburo, Manuel, Vinci, Maria Cristina, Colombo, Gualtiero I., Raucci, Angela |
| المصدر: |
International Journal of Molecular Sciences; Oct2022, Vol. 23 Issue 19, p11130, 16p |
| مصطلحات موضوعية: |
ADVANCED glycation end-products, FATTY acid oxidation, TRANSCRIPTOMES, INTERFERON gamma, ANTIGEN processing, RECEPTOR for advanced glycation end products (RAGE) |
| مستخلص: |
Cardiac aging is characterized by increased cardiomyocyte hypertrophy, myocardial stiffness, and fibrosis, which enhance cardiovascular risk. The receptor for advanced glycation end-products (RAGE) is involved in several age-related diseases. RAGE knockout (Rage−/−) mice show an acceleration of cardiac dimension changes and interstitial fibrosis with aging. This study identifies the age-associated cardiac gene expression signature induced by RAGE deletion. We analyzed the left ventricle transcriptome of 2.5-(Young), 12-(Middle age, MA), and 21-(Old) months-old female Rage−/− and C57BL/6N (WT) mice. By comparing Young, MA, and Old Rage−/− versus age-matched WT mice, we identified 122, 192, and 12 differently expressed genes, respectively. Functional inference analysis showed that RAGE deletion is associated with: (i) down-regulation of genes involved in antigen processing and presentation of exogenous antigen, adaptive immune response, and cellular responses to interferon beta and gamma in Young animals; (ii) up-regulation of genes related to fatty acid oxidation, cardiac structure remodeling and cellular response to hypoxia in MA mice; (iii) up-regulation of few genes belonging to complement activation and triglyceride biosynthetic process in Old animals. Our findings show that the age-dependent cardiac phenotype of Rage−/− mice is associated with alterations of genes related to adaptive immunity and cardiac stress pathways. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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