التفاصيل البيبلوغرافية
| العنوان: |
Synchronous primary cutaneous melanomas: a descriptive study of their clinical features, histology, genetic background of the patients and clinical outcomes. |
| المؤلفون: |
Antúnez‐Lay, A., Podlipnik, S., Carrera, C., Potrony, M., Tell‐Martí, G., Badenas, C., Puig‐Butille, J.A., Espinosa, N., Puig, S., Malvehy, J. |
| المصدر: |
Journal of the European Academy of Dermatology & Venereology; Dec2022, Vol. 36 Issue 12, p2364-2372, 9p |
| مصطلحات موضوعية: |
MELANOMA, BRAF genes, CYCLIN-dependent kinase inhibitor-2A, OLDER patients, HISTOLOGY, SURVIVAL rate, GENETIC variation, TREATMENT effectiveness |
| مستخلص: |
Background: Around 0.5% of cutaneous melanoma (CM) patients will present with synchronous melanomas when first seen. Moreover, 26–40% of patients with multiple primary melanomas present with synchronous lesions. Objectives: To assess the prevalence, clinical and histopathological characteristics, germline mutations and outcome in patients with synchronous melanoma. Methods: Clinical and histopathological data from 4703 melanoma patients were included. Clinical, histological and genetic mutational status information was analysed. Kaplan–Meier curves were used to investigate survival outcomes. Results: A total of 144 patients (3.06%) presented simultaneously with two or more primary melanomas. During follow‐up, 25.7% of patients with synchronous melanoma developed a new primary melanoma compared to 8.6% of patients diagnosed with single melanoma (P < 0.001). Germinal CDKN2A mutations were identified in 10.7% of patients with synchronous melanomas and genetic variants in MC1R in 72%. No significant differences in all survival outcomes between patients with synchronous melanomas and single melanomas were found. Conclusion: Synchronous melanomas are more frequent than previously reported and are more frequent in older patients compared to single melanomas. Moreover, these patients have a higher risk of developing a new primary melanoma during follow‐up and have higher rates of germline susceptibility variants. Nevertheless, these findings were not associated with worse outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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