التفاصيل البيبلوغرافية
| العنوان: |
Immunosuppression follows systemic T lymphocyte activation in the burn patient. |
| المؤلفون: |
Teodorczyk-Injeyan, J. A., Sparkes, B. G., Mills, G. B., Peters, W. J. |
| المصدر: |
Clinical & Experimental Immunology; Sep1991, Vol. 85 Issue 3, p515-518, 4p |
| مصطلحات موضوعية: |
MOLECULAR mechanisms of immunosuppression, LYMPHOCYTE transformation, IMMUNOREGULATION, T cells, BURNS & scalds, INTERLEUKIN-2, IMMUNE response |
| مستخلص: |
A general consensus that thermal injury affects T lymphocyte function adversely is supported particularly by the observation that burned patients' lymphocytes secrete reduced levels of biologically active IL-2 in vitro. In the same patients, however, high serum concentrations of the low affinity IL-2 receptor (IL2Rα), a product of an IL-2-activated gene, have been observed. In this study a significant proportion of patients also demonstrated over-physiological levels (from 2 to 500 U/ml) of serum IL-2 ascertained by immunoassay. Increases in serum IL-2 content correlated significantly (P < 0.02) with those of serum IL-2Rα during the first week post-burn. Later, serum IL-2Rα levels continued to increase up to 30 days while IL-2 eventually declined. Thus, augmented secretion of IL- 2Rα appears related to the high serum IL-2 content. Therefore refractoriness to further immune stimulation may be due to early activation of the lymphoid system, rather than to an intrinsic incapacity of T lymphocytes for generating sequential responses. [ABSTRACT FROM AUTHOR] |
|
Copyright of Clinical & Experimental Immunology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder