التفاصيل البيبلوغرافية
| العنوان: |
Cardiovascular risk assessment after anti-TNF treatment in patients with rheumatoid arthritis and ankylosing spondylitis with Strain Echocardiography. |
| Alternate Title: |
Romatoid artrit ve ankilozan spondilit hastalarında anti-TNF tedavisi sonrası Strain Ekokardiyografi ile kardiyovasküler risk değerlendirmesi. (Turkish) |
| المؤلفون: |
Yönak, Aslı Karadeniz, Dayan, Akın, Özen, Gülsen, Sünbül, Murat, Atagündüz, Mehmet Pamir, İnanç, Nevsun |
| المصدر: |
Journal of Turkish Society for Rheumatology; 2022, Vol. 14 Issue 3, p117-123, 7p |
| مصطلحات موضوعية: |
CARDIOVASCULAR diseases risk factors, RHEUMATOID arthritis, SPONDYLITIS, ECHOCARDIOGRAPHY, TUMOR necrosis factors |
| Abstract (English): |
Objective: The aim of this study was to investigate the effects of antitumor necrosis factor (anti-TNF) agents on myocardial function and cardiovascular risk factors in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients receiving anti-TNF agents for inflammatory arthritis for six months by using standard and speckle tracking echocardiography. Methods: The study was conducted on a group of 30 patients composed of 12 with RA and 18 with AS. Demographic, standard and speckle tracking echocardiographic data, disease activities, laboratory results related to our research were prospectively assessed. Results: In the study, there was a statistically significant decrease in disease activity score, Bath Ankylosing Spondylitis Disease Activity index, Health Assessment Questionnaire, and Bath Ankylosing Spondylitis Functional Index scores and erythrocyte sedimentation rate, C-reactive protein values of patients with RA and AS in the sixth month of anti-TNF treatment. There was a decrease in left ventricular global longitudinal strain values assessed with speckle tracking echocardiography in the sixth month compared to the baseline and this difference was statistically significant. Conclusion: Myocardial strain imaging might be useful in assessing the early development of cardiac failure in patients with high cardiovascular risk, such as patients with RA and AS. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Amaç: Çalışmanın amacı, romatoid artrit (RA) ve ankilozan spondilit (AS) hastalarında, altı ay süreyle anti-tümör nekroz faktörü (anti-TNF) kullanımının miyokard fonksiyonu ve kardiyovasküler risk faktörleri üzerindeki etkilerini standart ve speckle tracking ekokardiyografi kullanarak araştırmaktır. Yöntem: Çalışmaya 12 RA ve 18 AS olmak üzere toplam 30 hasta dahil edildi. Araştırmamızla ilgili demografik, standart ve speckle tracking ekokardiyografik veriler, hastalık aktiviteleri, laboratuvar sonuçları prospektif olarak değerlendirildi. Bulgular: Çalışmada anti-TNF tedavisinin altıncı ayında RA ve AS'li hastaların hastalık aktivite skoru, Bath Ankilozan Spondilit Hastalık Aktivite indeksi, Sağlık Değerlendirme Anketi ve Bath Ankilozan Spondilit Fonksiyonel İndeksi skorlarında ve eritrosit sedimentasyon hızında, C-reaktif protein değerlerinde istatistiksel olarak anlamlı düşüş saptandı. Speckle tracking ekokardiyografi ile değerlendirilen sol ventrikül global longitudinal strain değerlerinde başlangıca kıyasla altıncı ayda istatistiksel olarak anlamlı azalma olduğu saptandı. Sonuç: Miyokardiyal strain görüntülemesi RA ve AS'li hastalar gibi yüksek kardiyovasküler riski olan hastalarda kalp yetmezliğinin erken gelişimini değerlendirmede yararlı olabilir. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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