التفاصيل البيبلوغرافية
| العنوان: |
Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight. |
| المؤلفون: |
Tudu, Champa Keeya, Bandyopadhyay, Anustup, Kumar, Manoj, Radha, Das, Tuyelee, Nandy, Samapika, Ghorai, Mimosa, Gopalakrishnan, Abilash Valsala, Proćków, Jarosław, Dey, Abhijit |
| المصدر: |
Naunyn-Schmiedeberg's Archives of Pharmacology; Feb2023, Vol. 396 Issue 2, p229-238, 10p |
| مصطلحات موضوعية: |
PROTOZOAN diseases, DNA synthesis, NATURAL products, DATABASE searching, ASCLEPIADOIDEAE |
| مستخلص: |
Cryptolepine (1,5-methyl-10H-indolo[3,2-b]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr (family: Periplocaceae), is associated with the suppression of cancer and protozoal infections. Cryptolepine also exhibits anti-bacterial, anti-fungal, anti-hyperglycemic, antidiabetic, anti-inflammatory, anti-hypotensive, antipyretic, and antimuscarinic properties. This review of the latest research data can be exploited to create a basis for the discovery of new cryptolepine-based drugs and their analogues in the near future. PubMed, Scopus, and Google Scholar databases were searched to select and collect data from the existing literature on cryptolepine and their pharmacological properties. Several in vitro studies have demonstrated the potential of cryptolepine A as an anticancer and antimalarial molecule, which is achieved through inhibiting DNA synthesis and topoisomerase II. This review summarizes the recent developments of cryptolepine pharmacological properties and functional mechanisms, providing information for future research on this natural product. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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