التفاصيل البيبلوغرافية
| العنوان: |
PERSONALIZED TREATMENT OF OBSTRUCTIVE SLEEP APNEA: IS IT STILL A LONG WAY OFF? |
| Alternate Title: |
PERSONALIZOVANA TERAPIJA OPSTRUKTIVNE SLEEP APNEJE - KOLIKO SMO DALEKO? (Bosnian) |
| المؤلفون: |
Stamenković, Zoran, Ristić, Lidija, Pejčić, Tatjana, Jovanović, Hristina, Trajković, Hristina, Bjelaković, Marko, Cvetković, Jelena, Matejić, Ivan |
| المصدر: |
Acta Medica Medianae; 2022, Vol. 61 Issue 4, p54-62, 9p |
| مصطلحات موضوعية: |
SLEEP apnea syndromes, CONTINUOUS positive airway pressure, CHRONOBIOLOGY disorders |
| Abstract (English): |
The combination of sleep fragmentation, intermittent hypoxia exposure and circadian rhythm misalignment is crucial to represent multiple obstructive sleep apnea (OSA) clinical scenarios. Treatment of OSA has traditionally been directed to anatomical component treatment, implying the application of continuous positive airway pressure (CPAP) therapy, oral devices, upper airways surgery, weight loss, and positional therapy. These therapeutic approaches may be frustrating, especially in patients who fail to tolerate CPAP therapy, they may require personal engagement and are hardly maintained, or they have variable and hardly predictable efficacy. So, new treatment approaches aiming at specific, treatable, phenotype characteristics of OSA are needed as alternative therapeutic options. [ABSTRACT FROM AUTHOR] |
| Abstract (Bosnian): |
Kombinacija fragmentacije sna, povremene izloženosti hipoksiji i neusklađenosti cirkardijalnog ritma presudna je za ispoljavanje višestrukih kliničkih scenarija opstruktivne sleep apneje (OSA). Lečenje OSA tradicionalno je usmereno na lečenje anatomske komponente i podrazumeva primenu terapije kontinuiranim pozitivnim pritiskom (CPAP) tokom sna, primenu oralnih aparata, operacije gornjih disajnih puteva, gubitak težine i pozicionu terapiju. Ovakav pristup lečenju može biti frustrirajući, posebno za bolesnike, koji ne tolerišu CPAP terapiju, zahteva veliko lično angažovanje i teško je održiv ili ima promenljivu i teško predvidljivu efikasnost. Dakle, novi terapijski pristupi, koji ciljaju specifične, lečive, fenotipske karakteristike OSA, neophodni su kao alternativa. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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