التفاصيل البيبلوغرافية
| العنوان: |
Vonoprazan and high‐dose amoxicillin dual therapy for Helicobacter pylori first‐line eradication: A single‐arm, interventional study. |
| المؤلفون: |
Sue, Soichiro, Kondo, Masaaki, Sato, Takeshi, Oka, Hiroyuki, Sanga, Katsuyuki, Ogashiwa, Tsuyoshi, Matsubayashi, Mao, Kaneko, Hiroaki, Irie, Kuniyasu, Maeda, Shin |
| المصدر: |
JGH Open; Jan2023, Vol. 7 Issue 1, p55-60, 6p |
| مصطلحات موضوعية: |
CLINICAL trials, HELICOBACTER pylori, AMOXICILLIN, ANTIGEN analysis, RANDOMIZED controlled trials |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
Background: To date, no interventional trial has assessed the efficacy and safety of vonoprazan and high‐dose (500 mg four times daily, 2000 mg/day) amoxicillin dual therapy in terms of Helicobacter pylori eradication. We explored whether this was an appropriate first‐line treatment. Methods: This prospective, dual‐center, single‐arm interventional study was performed in Japan. Twenty H. pylori‐positive patients lacking any eradication history were treated with vonoprazan 20 mg twice daily and amoxicillin 500 mg four times daily (qid) for 7 days. Eradication was evaluated using a stool H. pylori antigen test. We evaluated safety using patient questionnaires. This study was registered in the jRCT database (jRCT031200128). Results: The intention‐to‐treat and per‐protocol eradication rates were 90% (95% confidence interval [CI] 68.3–98.8%, n = 20) and 94.4% (95% CI 72.7–99.9%, n = 18) respectively. No significant adverse event was recorded. Conclusion: Vonoprazan/high‐dose amoxicillin dual therapy can be a safe standard first‐line therapy. We are now undergoing a randomized controlled trial comparing dual therapy and vonoprazan‐based triple therapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of JGH Open is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder