دورية أكاديمية
Stimulation of Xenopus oocyte Na+,K+ATPase by the serum and glucocorticoid-dependent kinase sgk1.
العنوان: | Stimulation of Xenopus oocyte Na+,K+ATPase by the serum and glucocorticoid-dependent kinase sgk1. |
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المؤلفون: | Setiawan, Iwan, Henke, Guido, Feng, Yuxi, Böhmer, Christoph, Vasilets, Larisa A., Schwarz, Wolfgang, Lang, Florian |
المصدر: | Pflügers Archiv: European Journal of Physiology; Jun2002, Vol. 444 Issue 3, p426-431, 6p |
مصطلحات موضوعية: | SERUM, GLUCOCORTICOIDS, XENOPUS, EPITHELIAL cells, ALDOSTERONE, VENTILATION |
مستخلص: | The serum and glucocorticoid-dependent kinase-1 (sgk1) is expressed in a wide variety of tissues including renal epithelial cells. As it is up-regulated by aldosterone, it is considered to participate in the regulation of renal Na+ reabsorption. Indeed, co-expression of sgk1 with the renal epithelial Na+ channel (ENaC) augments Na+ channel activity. The aim of the present study was to examine possible effects of sgk1 on Na+/K+-ATPase activity. To this end dual-electrode voltage-clamp experiments were performed in Xenopus oocytes expressing the active kinase S422Dsgk1 or the inactive mutant K127Nsgk1. Na+/K+-ATPase activity was estimated from the hyperpolarization (ΔV |
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قاعدة البيانات: | Complementary Index |
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