التفاصيل البيبلوغرافية
| العنوان: |
Efficacy and safety of acupuncture as a complementary therapy for sepsis: a systematic review and meta-analysis. |
| المؤلفون: |
Xian, Jin, Wang, Ling, Zhang, Changyun, Wang, Jian, Zhu, Yushuo, Yu, Huijuan, Zhang, Xin, Tan, Qiwen |
| المصدر: |
Acupuncture in Medicine; Feb2023, Vol. 41 Issue 1, p3-15, 13p |
| مصطلحات موضوعية: |
ONLINE information services, MEDICAL databases, INTERLEUKINS, META-analysis, MEDICAL information storage & retrieval systems, HLA-B27 antigen, CONFIDENCE intervals, ACUPUNCTURE, SYSTEMATIC reviews, CALCITONIN, SEPSIS, TREATMENT effectiveness, LEUKOCYTE count, TUMOR necrosis factors, CD4 lymphocyte count, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, MEDLINE, COMBINED modality therapy, DATA analysis software, ODDS ratio, LACTIC acid, INTRA-abdominal pressure, LYMPHOCYTE count, MONOCYTES, EVALUATION |
| مستخلص: |
Background: Sepsis is a life-threatening organ dysfunction caused by dysregulation of the host response to infection. Acupuncture is used for treatment of inflammatory diseases; however, its effectiveness and safety as a complementary therapy for sepsis has not been fully explored. Methods: Data were retrieved from eight databases. Randomized controlled trials (RCTs) that compared acupuncture plus conventional therapies versus conventional therapies alone were included. Pre-specified primary outcomes were mortality at 28 days and Acute Physiologic and Chronic Health Evaluation (APACHE) II scores. Results: A total of 17 studies with 1099 participants were included in this study. In terms of the primary outcomes, acupuncture plus routine therapy reduced mortality at 28 days (risk ratio (RR)): 0.69, 95% confidence interval (CI): 0.52 to 0.91, p < 0.001) and APACHE II scores (mean difference (MD): −2.84, 95% CI: −4.09 to −1.58, p < 0.001) at day 7 after treatment compared with routine therapy alone. In terms of secondary outcomes, acupuncture plus routine therapy reduced white blood cell counts and levels of procalcitonin (PCT), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lactic acid and intra-abdominal pressure (IAP), and improved CD3+, CD4+ and monocytes of human leukocyte antigen (HLA)-DR at day 7 after treatment compared with routine therapy alone. However, acupuncture plus routine therapy had no significant effects on levels of IL-10, C-reactive protein (CRP), CD8+ and CD4+/CD8+ ratios compared with routine therapy alone. Quality of evidence was low to very low for all parameters (GRADE). Conclusion: The available evidence showed that combination of acupuncture and routine therapy may have benefit for sepsis compared with use of routine therapy only. Due to the low degree of certainty regarding its effects, further research is required. Trial registration number: ICRD42019141491 (PROSPERO). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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