التفاصيل البيبلوغرافية
| العنوان: |
Association between Methylene-Tetrahydrofolate Reductase C677T Polymorphism and Human Immunodeficiency Virus Type 1 Infection in Morocco. |
| المؤلفون: |
Baba, Hanâ, Bouqdayr, Meryem, Saih, Asmae, Bensghir, Rajaa, Ouladlahsen, Ahd, Sodqi, Mustapha, Marih, Latifa, Zaidane, Imane, Kettani, Anass, Abidi, Omar, Wakrim, Lahcen |
| المصدر: |
Laboratory Medicine; Jan2023, Vol. 54 Issue 1, p23-29, 7p |
| مصطلحات موضوعية: |
FOLIC acid metabolism, HIV infections, VITAMIN B12, CONFIDENCE intervals, GENETIC polymorphisms, CASE-control method, TREATMENT effectiveness, RISK assessment, DISEASE susceptibility, OXIDOREDUCTASES, ODDS ratio, AIDS |
| مصطلحات جغرافية: |
MOROCCO |
| مستخلص: |
Human immunodeficiency virus type 1 (HIV-1) infection varies substantially among individuals. One of the factors influencing viral infection is genetic variability. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been correlated with different types of pathologies, including HIV-1. The MTHFR gene encodes the MTHFR enzyme, an essential factor in the folate metabolic pathway and in maintaining circulating folate and methionine at constant levels, thus preventing the homocysteine accumulation. Several studies have shown the role of folate on CD4+ T lymphocyte count among HIV-1 subjects. In this case-control study we aimed to determine the association between the MTHFR C677T polymorphism and HIV-1 infection susceptibility, AIDS development, and therapeutic outcome among Moroccans. The C677T polymorphism was genotyped by polymerase chain reaction followed by fragment length polymorphism digestion in 214 participants living with HIV-1 and 318 healthy controls. The results of the study revealed no statistically significant association between MTHFR C677T polymorphism and HIV-1 infection (P > .05). After dividing HIV-1 subjects according to their AIDS status, no significant difference was observed between C677T polymorphism and AIDS development (P > .05). Furthermore, regarding the treatment response outcome, as measured by HIV-1 RNA viral load and CD4+ T cell counts, no statistically significant association was found with MTHFR C677T polymorphism. We conclude that, in the genetic context of the Moroccan population, MTHFR C677T polymorphism does not affect HIV-1 infection susceptibility, AIDS development, or response to treatment. However, more studies should be done to investigate both genetic and nutritional aspects for more conclusive results. [ABSTRACT FROM AUTHOR] |
|
Copyright of Laboratory Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder