التفاصيل البيبلوغرافية
| العنوان: |
Patterns of care and survival of Chinese glioblastoma patients in the temozolomide era: a Hong Kong population-level analysis over a 14-year period. |
| المؤلفون: |
Woo, Peter Y M, Yau, Stephen, Lam, Tai-Chung, Pu, Jenny K S, Li, Lai-Fung, Lui, Louisa C Y, Chan, Danny T M, Loong, Herbert H F, Lee, Michael W Y, Yeung, Rebecca, Kwok, Carol C H, Au, Siu-Kie, Tan, Tze-Ching, Kan, Amanda N C, Chan, Tony K T, Mak, Calvin H K, Mak, Henry K F, Ho, Jason M K, Cheung, Ka-Man, Tse, Teresa P K |
| المصدر: |
Neuro-Oncology Practice; Feb2023, Vol. 10 Issue 1, p50-61, 12p |
| مصطلحات موضوعية: |
CHINESE people, TEMOZOLOMIDE, KARNOFSKY Performance Status, SURVIVAL rate, OVERALL survival |
| مصطلحات جغرافية: |
HONG Kong (China) |
| مستخلص: |
Background The aim of this study is to address the paucity of epidemiological data regarding the characteristics, treatment patterns and survival outcomes of Chinese glioblastoma patients. Methods This was a population-level study of Hong Kong adult (> 18 years) Chinese patients with newly diagnosed histologically confirmed glioblastoma between 2006 and 2019. The age standardized incidence rate (ASIR), patient-, tumor- treatment-related characteristics, overall survival (OS) as well as its predictors were determined. Results One thousand and ten patients with a median follow-up of 10.0 months were reviewed. The ASIR of glioblastoma was 1.0 per 100 000 population with no significant change during the study period. The mean age was 57 + 14 years. The median OS was 10.6 months (IQR: 5.2–18.4). Independent predictors for survival were: Karnofsky performance score > 80 (adjusted OR: 0.8; 95% CI: 0.6–0.9), IDH-1 mutant (aOR: 0.7; 95% CI: 0.5–0.9) or MGMT methylated (aOR: 0.7; 95% CI: 0.5–0.8) glioblastomas, gross total resection (aOR: 0.8; 95% CI: 0.5–0.8) and temozolomide chemoradiotherapy (aOR 0.4; 95% CI: 0.3–0.6). Despite the significant increased administration of temozolomide chemoradiotherapy from 39% (127/326) of patients in 2006–2010 to 63% (227/356) in 2015–2019 (P -value <.001), median OS did not improve (2006–2010: 10.3 months vs 2015–2019: 11.8 months) (OR: 1.1; 95% CI: 0.9–1.3). Conclusions The incidence of glioblastoma in the Chinese general population is low. We charted the development of neuro-oncological care of glioblastoma patients in Hong Kong during the temozolomide era. Although there was an increased adoption of temozolomide chemoradiotherapy, a corresponding improvement in survival was not observed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
