التفاصيل البيبلوغرافية
| العنوان: |
Impairment of T cell activation in burn patients: a possible mechanism of thermal injury--induced immunosuppression. |
| المؤلفون: |
Teodorczyk-Injeyan, Julita A., Sparkes, B. G., Mills, G. B., Petfrs, W. J., Falk, R. E. |
| المصدر: |
Clinical & Experimental Immunology; Sep1986, Vol. 65 Issue 3, p570-581, 12p |
| مصطلحات موضوعية: |
T cells, CELL proliferation, LYMPHOCYTES, IMMUNOGLOBULINS, ANTIGENS, IMMUNOSUPPRESSION |
| مستخلص: |
In the burn patient, the mechanisms leading to impaired T lymphocyte activity are unclear. The capacity for T cell proliferation and the expression of Tac antigen (IL-2 receptor) was assessed during the post-burn period in patients with injuries ranging from 5-68%, total body surface area. T cell-dependent (polyclonal) immunoglobulin synthesis, mixed lymphocyte reaction and Interleukin-2 production were also determined in these patients and correlated with survival. Surviving patients demonstrated a transient reduction while terminal patients exhibited a permanent reduction in the number of Tac lymphocytes, unrelated to the absolute number of T cells, during the post-burn period. The reduced percentage of lL-2 receptor-expressing T cells coincided with the suppressed antibody response and reduced alloreactivity. Although the concentration of IL -2 was decreased in all patients throughout the hospitalization period, surviving patients showed a gradual increase in its production while terminal patients gradually decreased to undetectable levels. Exogenous recombinant IL-2 induced a significant enhancement of in-vitro polyclonal immunoglobulin production and blastogenesis in the mixed lymphocyte reaction in immunosuppressed patients who demonstrated up to 50%, reduction in the percentage of IL-2 receptor positive cells. Thus, the reduced capacity for production of and response to lL-2 alter thermal injury may lead to the immunosuppression due to a lack of T lymphocyte clonal expansion. The permanent nature of this detect in patients who died from fatal sepsis may suggest a causative relationship. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
