التفاصيل البيبلوغرافية
| العنوان: |
Prognostic value of P-wave morphology in general population. |
| المؤلفون: |
Laitinen, Idamaria, Kenttä, Tuomas V, Passi, Jussi, Haukilahti, Mira Anette E, Eranti, Antti, Holkeri, Arttu, Aro, Aapo L, Kerola, Tuomas, Noponen, Kai, Seppänen, Tapio, Rissanen, Harri, Knekt, Paul, Heliövaara, Markku, Ukkola, Olavi H, Junttila, M Juhani, Huikuri, Heikki V, Perkiömäki, Juha S |
| المصدر: |
EP: Europace; Jan2023, Vol. 25 Issue 1, p164-174, 11p |
| مستخلص: |
Aims To evaluate the prognostic significance of novel P-wave morphology descriptors in general population. Methods and results Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000–1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995–1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997–1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005–1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002–1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000–1.005, P = 0.03). Conclusion Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD. [ABSTRACT FROM AUTHOR] |
|
Copyright of EP: Europace is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder