التفاصيل البيبلوغرافية
| العنوان: |
An HLA-G/SPAG9/STAT3 axis promotes brain metastases. |
| المؤلفون: |
Bassey-Archibong, Blessing Iquo, Chokshi, Chirayu Rajendra, Aghaei, Nikoo, Kielisze, Agata Monika, Tatari, Nazanin, McKenna, Dillon, Singh, Mohini, Subapanditha, Minomi Kalpana, Parmar, Arun, Mobilio, Daniel, Savage, Neil, Lam, Fred, Tokar, Tomas, Provias, John, Yu Lu, Chafe, Shawn Christopher, Swanton, Charles, Hynds, Robert Edward, Venugopal, Chitra, Singh, Sheila Kumari |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 2/21/2023, Vol. 120 Issue 8, p1-9, 35p |
| مصطلحات موضوعية: |
BRAIN metastasis, BRAIN tumors, BRAIN damage, RNA sequencing, HISTOCOMPATIBILITY class I antigens |
| مستخلص: |
Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the brain metastatic cascade--the "premetastatic" or early stage when they first colonize the brain and the established macrometastatic stage. RNA sequencing was used to obtain the transcriptional profiles of premetastatic and macrometastatic (non-premetastatic) lung, breast, and melanoma BMICs. We identified that lung, breast, and melanoma premetastatic BMICs share a common transcriptomic signature that is distinct from their non-premetastatic counterparts. Importantly, we show that premetastatic BMICs exhibit increased expression of HLA-G, which we further demonstrate functions in an HLA-G/SPAG9/STAT3 axis to promote the establishment of brain metastatic lesions. Our findings suggest that unraveling the molecular landscape of premetastatic BMICs allows for the identification of clinically relevant targets that can possibly inform the development of preventive and/or more efficacious BM therapies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
