التفاصيل البيبلوغرافية
| العنوان: |
The risks associated with percutaneous native kidney biopsies: a prospective study. |
| المؤلفون: |
Andrulli, Simeone, Rossini, Michele, Gigliotti, Giuseppe, Manna, Gaetano La, Feriozzi, Sandro, Aucella, Filippo, Granata, Antonio, Moggia, Elisabetta, Santoro, Domenico, Manenti, Lucio, Infante, Barbara, Ferrantelli, Angelo, Cianci, Rosario, Giordano, Mario, Giannese, Domenico, Seminara, Giuseppe, Luca, Marina Di, Bonomini, Mario, Spatola, Leonardo, Bruno, Francesca |
| المصدر: |
Nephrology Dialysis Transplantation; Mar2023, Vol. 38 Issue 3, p655-663, 9p |
| مصطلحات موضوعية: |
RENAL biopsy, LONGITUDINAL method, ODDS ratio, LOGISTIC regression analysis, BLOOD transfusion, BLOOD transfusion reaction |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Background The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quantify biopsy-related complication rates in Italy. Methods The study examined the results of native kidney biopsies performed in 54 Italian nephrology centres between 2012 and 2020. The primary outcome was the rate of major complications 1 day after the procedure, or for longer if it was necessary to evaluate the evolution of a complication. Centre and patient risk predictors were analysed using multivariate logistic regression. Results Analysis of 5304 biopsies of patients with a median age of 53.2 years revealed 400 major complication events in 273 patients (5.1%): the most frequent was a ≥2 g/dL decrease in haemoglobin levels (2.2%), followed by macrohaematuria (1.2%), blood transfusion (1.1%), gross haematoma (0.9%), artero-venous fistula (0.7%), invasive intervention (0.5%), pain (0.5%), symptomatic hypotension (0.3%), a rapid increase in serum creatinine levels (0.1%) and death (0.02%). The risk factors for major complications were higher plasma creatinine levels [odds ratio (OR) 1.12 for each mg/dL increase, 95% confidence interval (95% CI) 1.08–1.17], liver disease (OR 2.27, 95% CI 1.21–4.25) and a higher number of needle passes (OR for each pass 1.22, 95% CI 1.07–1.39), whereas higher proteinuria levels (OR for each g/day increase 0.95, 95% CI 0.92–0.99) were protective. Conclusions This is the first multicentre prospective study showing that percutaneous native kidney biopsies are associated with a 5% risk of a major post-biopsy complication. Predictors of increased risk include higher plasma creatinine levels, liver disease and a higher number of needle passes. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nephrology Dialysis Transplantation is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder