التفاصيل البيبلوغرافية
| العنوان: |
Immune Checkpoint Inhibitor-Induced Primary Hyperparathyroidism in a Small-Cell Lung Cancer Patient: A Case Report. |
| المؤلفون: |
Zhang, Ying, Cui, Yangang, Li, Yan, Cong, Lei |
| المصدر: |
Medicina (1010660X); Feb2023, Vol. 59 Issue 2, p215, 7p |
| مصطلحات موضوعية: |
IMMUNE checkpoint proteins, DRUG side effects, HYPERPARATHYROIDISM, LUNG cancer, IMMUNE checkpoint inhibitors, HYPOPARATHYROIDISM, HYPOPHOSPHATEMIA |
| مستخلص: |
Immunotherapy is increasingly being used in the treatment of tumors. Adverse effects, however, are not uncommon, with the most common immune-related adverse events (IrAEs) including rash, fatigue, anemia, diarrhea, constipation, and elevated transaminase, among others. Rare IrAEs, which may include thrombocytopenia, hypoparathyroidism, pancreatitis glomerulonephritis, Guillain-Barré syndrome, and celiac disease, may also present. Immune checkpoint inhibitor (ICI)-induced primary hyperparathyroidism (PHPT) has not yet been reported on, and no research currently exists regarding its pathogenesis. We describe how a 50-year-old man diagnosed with advanced small-cell lung cancer (SCLC) developed severe PHPT after receiving the programmed cell death (PD)-1 inhibitor camrelizumab. The patient eventually died of respiratory failure and a progressive malignancy. We speculate that the hypercalcemia and hypophosphatemia observed in this case were secondary to ICI-induced PHPT. Although fatal PHPT is rare, early intervention may reduce the risk of future complications. Therefore, further exploration of the underlying mechanisms is needed to guide solutions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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