التفاصيل البيبلوغرافية
| العنوان: |
Extrinsic denervation alters postprandial absorption of glucose and glutamine in the ileum: implications for small bowel transplantation |
| المؤلفون: |
Libsch, Karen D., Zarroug, Abdalla E., Duininck, Troy M., Ueno, Tatsuya, Duenes, Judith A., Sarr, Michael G. |
| المصدر: |
Journal of Gastrointestinal Surgery; Feb2005, Vol. 9 Issue 2, p219-226, 8p |
| مصطلحات موضوعية: |
GLUCOSE, ELECTROLYTES, GLUTAMINE, OLEIC acid, ILEUM, GLUCOSE metabolism, GLUTAMINE metabolism, ILEUM innervation, ANIMAL experimentation, COMPARATIVE studies, DENERVATION, DOGS, GASTROINTESTINAL motility, INGESTION, INTESTINAL absorption, RESEARCH methodology, MEDICAL cooperation, RESEARCH, UNSATURATED fatty acids, EVALUATION research |
| مستخلص: |
In the postprandial period, augmentation of absorption of water, electrolytes, and taurocholate is believed to occur in the ileum. The role of extrinsic innervation in this postprandial augmentation has not been well studied and may be an important concept in small bowel transplantation. Our aim was to investigate extrinsic neural mechanisms mediating postprandial absorptive patterns. The study hypothesis was that postprandial augmentation of absorption in the ileum is blunted in transplanted (extrinsically denervated) bowel. Ileal absorption was studied in six dogs with an 80-cm in situ ileal segment via a triple-lumen perfusion technique using an iso-osmolar, ileal-like electrolyte solution alone and containing either glucose 2.5 mM, glutamine 2.5 mM, oleic acid 5 mM, or taurocholate 5 mM. Net absorptive fluxes of each substrate, as well as water and electrolytes, were measured in both the fasted state and after a 400-Kcal mixed meal before and at 2 and 12 weeks after our validated model of complete extrinsic denervation of the jejunoileum. At baseline, there were no differences in absorption of water, electrolytes, or any nutrient postprandially compared with the fasted state. Two weeks after extrinsic denervation, absorption of glucose at both 1 and 2 hours postprandially was decreased compared with absorption during fasting. Glutamine absorption was also decreased at 2 hours postprandially. At 12 weeks after extrinsic denervation, net postprandial absorption of glucose and glutamine returned toward normal and was not different from fasting absorption. No differences were noted in postprandial absorption of oleic acid or taurocholate at any time point. Decreases in absorption of nutrients postprandially after extrinsic denervation (which is necessitated by small bowel transplantation) may play an important role in post-transplant enteric absorptive dysfunction. The previously described postprandial augmentation in net absorption may be a function of enterically isolated gut and does not appear to occur in the in situ ileum. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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