التفاصيل البيبلوغرافية
| العنوان: |
REVISITING THE CELLULAR PHYSIOLOGY OF THE BRAIN: OXIDATIVE STRESS, NEUROGLOBIN AND HIF1? DYNAMICS IN REPEATED RESTRAINT STRESS CONDITIONS. |
| المؤلفون: |
POP, RĂZVAN, MARINESCU, MĂDĂLINA, CUTEAN, ANDREEA, MOLDOVAN, CLAUDIA, DRAGAN, ŞTEFAN, NUTU, ALEXANDRA, MOISE, CEZAR, SEVASTRE, BOGDAN, ROMAN, IOANA, TOMA, VLAD-ALEXANDRU |
| المصدر: |
Journal of Experimental & Molecular Biology; 2022, Vol. 23 Issue 2, p49-49, 1p |
| مصطلحات موضوعية: |
IMMOBILIZATION stress, BRAIN physiology, OXIDATIVE stress, NEUROGLIA, SUPEROXIDE dismutase, FETAL hemoglobin |
| مستخلص: |
Exposure of the body to stress has different effects on it, depending on the period of stress it was subjected to. While exposure for a short period of time can give the body certain benefits, chronic stress has mostly harmful effects. To prove this fact, Wistar male rats were subjected to repeated restraint stress for 3 and 7 days, 3 hrs/day. These procedures were followed by a series of biochemical, histochemical, and immunohistochemical analyzes to express the hypoxic background produced after the stress exposure. Therefore, the applied techniques and biochemical analyzes for brain tissue or brain lysates (cortical-thalamic area) are as follows: superoxide dismutase, catalase, TBARS, free leucine-like levels, total proteins, glucose, expression of the neuroglobin, and HIF1α as well as glial cells markers GFAP and CNP. As the data shows, the hypoxic background after 7 days of repeated stress exposure was a more severe one, due to the inability of the system to face oxidative stress. These data showed a stress balance reaction of the brain via oxygen sensing reactions and proliferating glial cells, in a time-dependent manner. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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