التفاصيل البيبلوغرافية
العنوان: |
Mitochondrial DNA copy number as a diagnostic marker and indicator of degree of severity in alopecia areata. |
المؤلفون: |
Shehata, Wafaa Ahmed, Hammam, Mostafa Ahmed, Abdo, Aya, Tayel, Nermin, Abdelsattar, Shimaa |
المصدر: |
Journal of Immunoassay & Immunochemistry; 2023, Vol. 44 Issue 3, p256-268, 13p |
مصطلحات موضوعية: |
MITOCHONDRIAL DNA, ALOPECIA areata, DNA, REFERENCE values |
مستخلص: |
Alopecia areata (AA) is a disorder with several etiologies. The evidence suggests that the absolute copy number of mitochondrial deoxyribonucleic acid (mtDNA), as well as proportion of mutated mtDNA copies, determines disease onset. This study aims to quantify the relative index of the mtDNA copy number in patients with AA and healthy controls and correlate the results with the existing clinical information. This case-control study included 50 patients with AA and 50 age- and sex-coordinated healthy persons as controls. The severity of AA was weighed using the Severity of Alopecia Tool and Kavak's classification. The relative index of the mtDNA copy number was measured by real-time qPCR. Significant statistical difference was observed between cases and controls regarding mean mtDNA copy number, p <.001. There was significant positive correlation with SALT score (p = 0.001). A cutoff value of >1.619 N/µL could significantly diagnose AA cases (p <.001), and a cutoff value of > 1.36 N/µL could discriminate mild AA cases from those with moderate AA (p = 0.007). The relative index of mtDNA copy number is significantly elevated in AA cases and could be helpful in diagnosing and evaluating AA severity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Immunoassay & Immunochemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |