التفاصيل البيبلوغرافية
| العنوان: |
DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair. |
| المؤلفون: |
Ye-Rim Lee, Gi-Sue Kang, Taerim Oh, Hye-Ju Jo, Hye-Joon Park, G-One Ahn |
| المصدر: |
Molecules & Cells (Korean Society for Molecular & Cellular Biology); Apr2023, Vol. 46 Issue 4, p200-205, 6p |
| مستخلص: |
DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a member of the phosphatidylinositol 3-kinase-related kinase family is a well-known player in repairing DNA double-strand break through non-homologous end joining pathway. This mechanism has allowed us to understand its critical role in T and B cell development through V(D)J recombination and class switch recombination, respectively. We have also learned that the defects in these mechanisms lead to the severely combined immunodeficiency (SCID). Here we highlight some of the latest evidence where DNA-PKcs has been shown to localize not only in the nucleus but also in the cytoplasm, phosphorylating various proteins involved in cellular metabolism and cytokine production. While it is an exciting time to unveil novel functions of DNA-PKcs, one should carefully choose experimental models to study DNAPKcs as the experimental evidence has been shown to differ between cells of defective DNA-PKcs and those of DNAPKcs knockout. Moreover, while there are several DNAPK inhibitors currently being evaluated in the clinical trials in an attempt to increase the efficacy of radiotherapy or chemotherapy, multiple functions and subcellular localization of DNA-PKcs in various types of cells may further complicate the effects at the cellular and organismal level. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
