التفاصيل البيبلوغرافية
| العنوان: |
Prognostic Nutritional Index as a Predictor of Prognosis in Postoperative Patients With Gastric Cancer. |
| المؤلفون: |
TETSUSHI ISHIGURO, TORU AOYAMA, MIHWA JU, KEISUKE KAZAMA, MOMOKO FUKUDA, HARUKA KANAI, SHO SAWAZAKI, HIROSHI TAMAGAWA, AYAKO TAMAGAWA, HARUHIKO CHO, KENTARO HARA, MASAKATSU NUMATA, ITARU HASHIMOTO, YUKIO MAEZAWA, KENKI SEGAMI, TAKASHI OSHIMA, AYA SAITO, NORIO YUKAWA, YASUSHI RINO |
| المصدر: |
In Vivo; May/Jun2023, Vol. 37 Issue 3, p1290-1296, 7p |
| مصطلحات موضوعية: |
NUTRITION, PROGNOSIS, POSTOPERATIVE care, STOMACH cancer, BLOOD testing |
| مستخلص: |
Background/Aim: The prognostic nutritional index (PNI) has been reported as an immunonutritional index that can easily evaluate nutritional status and immunocompetence from blood tests. The purpose of this study was to investigate the usefulness of PNI as a prognostic factor in postoperative gastric cancer patients. Patients and Methods: In this retrospective cohort study, we evaluated 258 patients with pStage I-III gastric cancer who underwent radical resection at Yokohama City University Hospital, from 2015 to 2021. To examine the association with prognosis, we analyzed clinicopathological factors including PNI (<47/=47), age (<75/=75), sex (male/female), depth (pT1/=pT2), lymph node metastasis (pN+/pN-), lymphatic invasion (ly+/ly-), vascular invasion (v+/v-), histological type (enteric/spread) and postoperative complications. Results: In univariate analysis, PNI (p<0.001), depth of tumor invasion (p<0.001), lymph node involvement (p<0.001), age (p=0.002), lymphatic invasion (p<0.001), vascular invasion (p<0.001), and postoperative complications (p=0.003) were associated with overall survival. In multivariate analysis, PNI (HR=2.100, 95% confidence interval 1.225-3.601, p=0.007), tumor invasion, lymph node metastasis, and postoperative complications were shown as poor prognostic factors for overall survival. Conclusion: PNI is an independent prognostic factor for overall and recurrence-free survival in postoperative gastric cancer patients. PNI could be implemented in clinical practice to identify patients at higher risk for poor outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
