التفاصيل البيبلوغرافية
| العنوان: |
The relationship between non-alcoholic fatty liver disease and incidence of chronic kidney disease for diabetic and non-diabetic subjects: A meta-analysis. |
| المؤلفون: |
Yueqiao Chen, Wenjie Bai, Dewen Mao, Fuli Long, Na Wang, Kejing Wang, Qinglan Shi |
| المصدر: |
Advances in Clinical & Experimental Medicine; Apr2023, Vol. 32 Issue 4, p407-414, 8p |
| مصطلحات موضوعية: |
NON-alcoholic fatty liver disease, CHRONIC kidney failure, FATTY liver, DISEASE risk factors, DIABETIC nephropathies, RANDOM effects model, COMORBIDITY |
| مستخلص: |
Introduction. The prevalence of chronic kidney disease (CKD) rises with age and co-morbid diseases such as liver diseases. Objectives. The main aim of the current meta-analysis is to assess the relationship between Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease incidence in both diabetic and non-diabetic subjects compared with control. Materials and methods. A systematic literature search of papers published from January 1, 2005, till April 30, 2022, found 19 studies including 1,111,046 subjects; 310,804 were diagnosed with NAFLD, and 800,242 were non-NAFLD. The measured outcome was the incidence of CKD among NAFLD subjects compared to non-NAFLD subjects in diabetic and non-diabetic subjects. Dichotomous analysis methods were used within the random effects model to calculate the odds ratio (OR) with 95% confidence intervals (95% CIs). Results. The incidence of CKD is highly significant in NAFLD subjects compared with controls (OR: 1.95; 95% CI: 1.65-2.31). The diabetic non-NAFLD subjects showed a significantly increased incidence of CKD compared to the non-diabetic subjects with NAFLD (OR: 1.79; 95% CI: 1.35-2.38). In addition, the incidence of CKD was significantly higher in the NAFLD group compared with the non-NAFLD non-diabetic subjects (OR: 2.52; 95% CI: 1.91-3.32). Diabetes acts as an independent risk factor for CKD, as proven by a significant increase in incidence of diabetic subjects compared to non-diabetic NAFLD subjects (OR: 1.82; 95% CI: 1.15-2.88). Conclusions. Non-alcoholic fatty liver disease is significantly related to an increased incidence of CKD, which is significantly higher in diabetic subjects. [ABSTRACT FROM AUTHOR] |
|
Copyright of Advances in Clinical & Experimental Medicine is the property of Wroclaw Medical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder