التفاصيل البيبلوغرافية
| العنوان: |
Intensive care unit requirements in patients treated with immune checkpoint inhibitors. |
| المؤلفون: |
Cooksley, Tim, Weaver, Jamie M J, Haji-Michael, Phil |
| المصدر: |
QJM: An International Journal of Medicine; Apr2023, Vol. 116 Issue 4, p285-287, 3p |
| مصطلحات موضوعية: |
INTENSIVE care patients, IMMUNE checkpoint inhibitors, IPILIMUMAB, MYASTHENIA gravis |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Objective To determine the proportion of emergency patients treated with immune checkpoint inhibitors (ICIs) that require critical care admission and their requirements. Design Prospective case series. Methods Analysis of acutely unwell patients treated with ICIs attending a tertiary UK cancer hospital between May 2018 and May 2022. The primary outcome measure was the percentage of patients treated with ICI therapy requiring ICU admission. The secondary outcome measure was whether this need was driven by an immune-mediated toxicity. Results Eighteen (1.2%) patients of the 1561 acutely admitted patients treated with ICI therapy required an admission to ICU. Ten (55.5%) patients were admitted due to an immune-mediated toxicity; four due to pneumonitis and four due to myasthenia gravis. Seven of 10 survived their ICU admission with 6 surviving at least 6-month post-ICU discharge. Conclusions Only a small minority of emergency admissions in patients treated with ICIs require admission to ICU. This series adds further evidence that patients with organ failure due to immune-mediated toxicity may achieve good outcomes from ICU admission. [ABSTRACT FROM AUTHOR] |
|
Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder