التفاصيل البيبلوغرافية
| العنوان: |
Analysis of Pharmacodynamic Substance Basis of Fufang Changtai in Treating Colorectal Cancer by UPLC-Q-TOF-MS Combined with Network Pharmacology. |
| المؤلفون: |
Jingbing LIU, Guanzheng LU, Xinyue SU, Ziyu JLANG, Xiaobin JIA, Shuaimei LIU, Liang FENG |
| المصدر: |
Medicinal Plant; Apr2023, Vol. 14 Issue 2, p8-14, 7p |
| مصطلحات موضوعية: |
COLORECTAL cancer, TIME-of-flight mass spectrometry, NANOTECHNOLOGY, MOLECULAR docking, MOLECULAR pharmacology, METABOLOMICS |
| مستخلص: |
[Objectives] To systematically study the main active components of Fufang Changtai (FFCT) in the treatment of colorectal cancer (CRC), and to explore its mechanism of action. [Methods] The main chemical components of FFCT were analyzed by ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) combined with automatic analysis platform, and the main pharmacodynamic substances of FFCT were studied by network pharmacology method and its mechanism of action was explored. The binding degree between the active components and the core targets were verified by molecular docking technology. [Results] A total of 86 compounds were identified from FFCT, among which 26 compounds were Ginsenoside Rg3, Ginsenoside Rbl, Astragaloside III, etc. The key target pathway enrichment analysis showed that FFCT played its role in the treatment of CRC mainly through the P13K-Akt signaling pathway and MAPK signaling pathway. [Conclusions] This study comprehensively identified the FFCT components. Supplemented by network pharmacology and molecular docking technology, it is expected to provide a scientific theoretical basis and an important reference for FFCT therapeutic components identification, key target verification and mechanism of action in the treatment of CRC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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