التفاصيل البيبلوغرافية
| العنوان: |
Edible Bird’s Nest as Potential Food with Anti-Viral and Anti-Inflammatory Properties Against Covid-19: an in Silico Study. |
| المؤلفون: |
Ningrum, Siti Gusti, Sasmita, Rochiman, Kharisma, Viol Dhea |
| المصدر: |
Acta Vet Indones. The Indonesian Veterinary Journal / Jurnal Acta Veterinaria Indonesiana; mar2023, Vol. 11 Issue 1, p43-50, 8p |
| مصطلحات موضوعية: |
EDIBLE birds' nests, ANTIVIRAL agents, COVID-19 pandemic, MOLECULAR docking, BIOACTIVE compounds |
| Abstract (English): |
The Chinese believe consuming edible bird’s nests (EBN) can increase immunity to various diseases, including Covid-19. This study attempts to identify SARS COV-2-specific anti-viral and anti-inflammatory agents of EBN. We gathered samples from PubChem and Protein Data Bank (PDB). Afterwards, drug likeness was examined using the Lipinski model from the SCFBIO online service. The PASS web server analyzed the bioactive likelihood of chemicals found in EBN. Using PyRx 0.8 software with the blind docking technique. The PoseView web server and PyMol v2.4.1 software were utilized to ascertain molecular interactions. The in silico results show the potential of EBN as food therapy for Covid-19 sufferers, which is indicated by the presence of bioactive compounds from edible bird’s nest consisting of 9-O-acetylated GD3, glycopeptide, N-acetyl neuraminic acid, N-glycolyl-neuraminic acid, sialic acid, and tetra acetyl-thymol-beta-D-glucoside. These bio compounds are predicted to work as anti-viral and antiinflammatory candidates against SARS-COV-2. [ABSTRACT FROM AUTHOR] |
| Abstract (Indonesian): |
Masyarakat Tionghoa percaya bahwa dengan mengkonsumsi sarang burung walet (SBW) dapat meningkatkan kekebalan tubuh terhadap berbagai penyakit, termasuk Covid-19. Penelitian ini bertujuan untuk mengidentifikasi agen anti-virus dan anti-inflamasi spesifik terhadap SARS COV-2 yang terkandung di dalam SBW. Sampel dikoleksi dari PubChem dan Protein Data Bank (PDB) yang selanjutnya dilakukan pemeriksaan drug likeness menggunakan model Lipinski dari layanan online SCFBIO. Kemungkinan bioaktif bahan kimia yang ditemukan dalam SBW dianalisis menggunakan server web PASS. Teknik blind docking digunakan dalam penelitian ini menggunakan perangkat lunak PyRx 0.8. Interaksi molekuler juga dianalisis dalam penelitian ini menggunakan server web PoseView dan perangkat lunak PyMol v2.4.1. Hasil studi in silico menunjukkan adanya potensi SBW sebagai terapi makanan bagi penderita Covid-19, yang ditunjukkan dengan adanya senyawa bioaktif dari sarang burung walet yang terdiri dari 9-O-acetylated GD3, glycopeptide, N-acetyl neuraminic acid, N- asam glikolyl-neuraminic, asam sialat, dan tetra asetil-timol-beta-D-glukosida. Senyawa bio tersebut diprediksi dapat bekerja sebagai kandidat anti virus dan anti inflamasi terhadap SARS-COV-2. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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