التفاصيل البيبلوغرافية
| العنوان: |
Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali. |
| المؤلفون: |
Oumar, Aboubacar Alassane, Seydou, Alassane, Fofana, Souleymane, Diarra, Zoumana, Mariko, Djeneba, Diallo, Abdallah, Coulibaly, Sanata, Sidibe, Lala N., Togo, Boubacar, Sounkalo Dao, Doumbia, Seydou, Tulkens, Paul M. |
| المصدر: |
Journal of Pediatric Pharmacology & Therapeutics; 2023, Vol. 28 Issue 3, p197-203, 7p |
| مصطلحات موضوعية: |
DRUG side effects, HIV-positive children, PATIENT compliance, HIV-positive persons, BIVARIATE analysis |
| مصطلحات جغرافية: |
BAMAKO (Mali), MALI |
| مستخلص: |
OBJECTIVE The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People Living With HIV (USAC) of Bamako. METHODS A cross-sectional study was conducted at USAC of Bamako from May 1, 2014, to July 31, 2015. We included children aged 1 to 14 years with at least 6 months of ARV treatment initiated at USAC, with or without ADRs. Data collection was based on information collected from parents and clinical/biological assessments. RESULTS Median age of participants was 36 months and female sex was predominant (54.8%). Poor adherence during the study was observed in 15% of cases. Of patients in the study, 52% had a CD4 count less than 350 cells/mm³ at the time of adverse events. In bivariate analysis, we found that participants with adherence to ART tended to be younger than those with non-adherence to ART (36 vs 72 months, p = 0.093). In multivariable analysis, prophylactic treatment was the only factor marginally associated with ART adherence in HIV patients (p = 0.09). No other adverse biological effects or clinical conditions were associated with ART adherence in this study. CONCLUSIONS In this study we found that ADRs were frequent in HIV-positive patients but less frequent in ART-adherent HIV-positive children. Therefore, it is essential to regularly monitor children receiving ARVs to detect and treat the complications associated with these therapies according to ART adherence. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
