التفاصيل البيبلوغرافية
| العنوان: |
Interactive Effects of Swimming Training and Cinnamon Supplementation on Changing Cardiac miR-133a and miR-21 in the Streptozotocin-Induced Diabetic Rats. |
| المؤلفون: |
Najafabadi, Marzieh Fazel, Keshavarz, Saeed, Hosseini, Seyed Ali, Eftekhari, Elham |
| المصدر: |
Journal of Nutrition, Fasting & Health; 2023, Vol. 11 Issue 1, p60-66, 7p |
| مصطلحات موضوعية: |
CINNAMON, SWIMMING training, STREPTOZOTOCIN, TREATMENT of diabetes, MICRORNA |
| مستخلص: |
Introduction: This study aimed to review the synergistic effects of swimming training (ST) and cinnamon supplementation (Cin) on changing cardiac miR-133a and miR-21 in streptozotocininduced diabetic rats. Methods: A total of 32 diabetic rats were selected as 1) ST+ Cin, 2) Cin, 3) ST and 4) diabetic control (DC) groups, and eight healthy rats were selected as the HC group. Groups 1 and 3 swam three sessions per week and 2-22 minutes each session for eight weeks. Groups 1 and 2 received 200mg/kg/day of aqueous Cin extract. qReal Time PCR method was used to measure the miR-21 and miR-133a gene expression in heart tissue. Results: MiR-133a and miR-21 gene expression in Cin, ST, and ST+Cin groups increased compared to the DC group (P=0.001), and miR-133a gene expression in the ST+Cin group enhanced compared to Cin and ST groups (P=0.001). MiR-21 gene expression in ST and ST+Cin groups increased compared to the Cin group. In addition, miR-21 gene expression in the ST+Cin group raised compared to the ST group (P=0.001). Conclusion: Although exercises lead to cardiac adaptations by creating oxidative stress, cinnamon can increase miR-133a as a cardio-protective agent and modulate miR-21 as a marker of cardiac damage. Therefore, cinnamon should be used along with exercises in cases of diabetes and heart disease. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Nutrition, Fasting & Health is the property of Mashhad University of Medical Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
