التفاصيل البيبلوغرافية
| العنوان: |
MOLECULAR CLUSTERING ON CTDNA IMPROVES THE PROGNOSTIC STRATIFICATION OF DLBCL PATIENTS COMPARED TO CTDNA LEVELS. |
| المؤلفون: |
Moia, R., Talotta, D., Dondolin, R., Almasri, M., Cosentino, C., Bruna, R., Della Starza, I., Soscia, R., Bruscaggin, A., Di Bergamo, L. Terzi, Andorno, A., Mercalli, F., Bomben, R., Bittolo, T., Vit, F., Bulian, P., Melle, F., Motta, G., Leutner, M., Mahmoud, A. M. |
| المصدر: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p174-175, 2p |
| مصطلحات موضوعية: |
MOLECULAR clusters, CIRCULATING tumor DNA, DIFFUSE large B-cell lymphomas |
| مستخلص: |
Interestingly, 80% of ST2/BN2 patients reached an early molecular response (EMR) and the 2 ST2/BN2 patients who did not achieve an EMR after 1 cycle of therapy are still in complete remission. Also in the validation cohort, patients with <2.5Log SB 10 sb hGE and/or assigned to cluster BN2 and ST2 presented an excellent outcome with a 40-month PFS and OS of 73.2% and 79.7%, compared to 39.2% and 44.8% for other patients, respectively (both I p i = 0.001) (Figure 1B). B Introduction: b The quantification of circulating tumor DNA (ctDNA) on the liquid biopsy at the time of diagnosis allows to stratify the outcome of diffuse large B-cell lymphoma (DLBCL) patients but its integration with molecular clustering has not been evaluated so far. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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