التفاصيل البيبلوغرافية
| العنوان: |
A Phase I Study of CD19‐targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory Diffuse Large B‐cell Lymphoma. |
| المؤلفون: |
Palomba, M. L., Riviere, I., Sikder, D. S., Senechal, B., Wang, X., Cathcart, E. R., Liotta, K., Li, J., Sellner, L., Sadelain, M., Chen, S., Zhao, Y., Park, J. H. |
| المصدر: |
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p527-528, 2p |
| مصطلحات موضوعية: |
DIFFUSE large B-cell lymphomas, T cells |
| مستخلص: |
B Background: b The redundancy of CD28 and CD3 signaling in a CAR design incorporating all 3 immunoreceptor tyrosine-based activation motifs (ITAMs) might negatively affect T cell differentiation and promote exhaustion. In mouse models, 19-28z1XX CAR successfully induced tumor eradication at low CAR T cell doses with improved survival compared to conventional 19-28z CAR and with enhanced persistence of functional CAR T cells. A Phase I Study of CD19-targeted 19(T2)28z1xx CAR T Cells in Adult Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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