التفاصيل البيبلوغرافية
| العنوان: |
Immunology of a unique biological structure: the Echinococcus laminated layer. |
| المؤلفون: |
Díaz, Álvaro, Barrios, Anabella A, Grezzi, Leticia, Mouhape, Camila, Jenkins, Stephen J, Allen, Judith E, Casaravilla, Cecilia |
| المصدر: |
Protein & Cell; Feb2023, Vol. 14 Issue 2, p87-104, 18p |
| مستخلص: |
The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species. The resulting diseases, collectively termed echinococcoses, include major neglected tropical diseases of humans and livestock. Echinococcus larvae are outwardly protected by the laminated layer (LL), an acellular structure that is unique to this genus. The LL is based on a fibrillar meshwork made up of mucins, which are decorated by galactose-rich O -glycans. In addition, in the species cluster termed E. granulosus sensu lato , the LL features nano-deposits of the calcium salt of myo -inositol hexakisphosphate (Ins p 6). The main purpose of our article is to update the immunobiology of the LL. Major recent advances in this area are (i) the demonstration of LL "debris" at the infection site and draining lymph nodes, (ii) the characterization of the decoy activity of calcium Ins p 6 with respect to complement, (iii) the evidence that the LL mucin carbohydrates interact specifically with a lectin receptor expressed in Kupffer cells (Clec4F), and (iv) the characterization of what appear to be receptor-independent effects of LL particles on dendritic cells and macrophages. Much information is missing on the immunology of this intriguing structure: we discuss gaps in knowledge and propose possible avenues for research. [ABSTRACT FROM AUTHOR] |
|
Copyright of Protein & Cell is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder